This is for a 6-month full-time co-op from July to December 2020.

The protein and cell engineering group, which is part of Biologics Drug Discovery, supports research projects across multiple program teams through construct design and generation, design and expression of recombinant proteins including antibodies and cell engineering for function-based candidate screening.

Position Description:

We seek a Co-op to join our protein and cell engineering group. The Co-op’s role will be to evaluate various strategies for antigen design to facilitate antibody discovery of challenging targets such as membrane proteins. The Coop will assess novel technologies related to antigen generation, make cell lines and perform antibody expression with impact across different project teams and therapeutic areas. This position will involve extensive use of protein and cell engineering methodologies and molecular biology.

Through this project the Co-op will learn skills including, but not limited to molecular biology techniques such as cloning, mammalian cell culture including stable cell line generation, flow cytometry sample preparation, protein expression and biochemistry techniques such as SDS PAGE and western blotting.

Additionally, the Co-op will learn to design experiments, set up appropriate controls, evaluate data, perform optimization, troubleshoot experiments, present results and work in a collaborative team-centric environment.

Key responsibilities include:

• Molecular biology and generation of constructs
• Transient transfection of cells and stable cell line generation
• Protein expression in CHO cells
• Assessment of cell surface expression of protein targets by flow cytometry

To participate in the Biogen Co-op Program, students must meet the following eligibility criteria:

• Legal authorization to work in the U.S.
• Grade point average of 3.2 or higher preferred
• At least 18 years of age prior to the scheduled start date
• Be currently enrolled in an accredited college or university

Additional qualifications include:

• Familiarity with mammalian tissue culture technique, handling of common cell lines and basic molecular biology
• Good oral and written communication
• Exceptional documentations skills
• Experience with assay design, especially flow cytometry binding assays is a plus

Education
Senior undergraduate student or Master’s degree candidate.

Biochemistry, Cell Biology, Structural biology, Biotechnology, Genetics majors preferred.

Location
Cambridge, MA

Relocation is not offered for this position.

All your information will be kept confidential according to EEO guidelines.