Bicycle Therapeutics is a clinical-stage pharmaceutical company developing a novel class of medicines, referred to as Bicycle® molecules, for diseases that are underserved by existing therapeutics. Bicycle molecules are fully synthetic short peptides constrained with small molecule scaffolds to form two loops that stabilize their structural geometry. This constraint facilitates target binding with high affinity and selectivity, making Bicycle molecules attractive candidates for drug development.

The company is evaluating nuzefatide pevedotin, a Bicycle® Drug Conjugate (BDC®) targeting EphA2 (a historically undruggable target), in addition to a pipeline of other Bicycle-based conjugate molecules. These include Bicycle® Radioconjugates (BRC®) for patient imaging and radiotherapy; zelenectide pevedotin, a BDC® currently in phase 2 clinical development and BT7480, a Bicycle Tumour-targeted Immune Cell Agonist® (Bicycle TICA®). The use of Bicycle® technology is also being explored to develop therapies for diseases in additional therapeutic areas through various partnerships.

Bicycle Therapeutics is headquartered in Cambridge, UK, with many key functions and members of its leadership team located in Lexington, Massachusetts US.

Culture is key and all Bicycle employees actively embrace and role model our company values:  

• We are Adventurous. We believe it's the way to deliver extraordinary results for our patients.
• We are Dedicated to our Mission. You can't change the world if you don't have determination
• We are One Team. We only succeed when we work together. 

You will be the operational engine of the IT function, driving excellence and seamless execution across the entire IT project portfolio.

In this role, you will bridge the gap between strategy and execution, supporting portfolio delivery, leading high-impact artificial intelligence (AI) initiatives and holding full accountability for software license procurement to secure the absolute best commercial and operational outcomes for Bicycle Therapeutics (BCYC).

Success in this role will be measured by your ability to work seamlessly across BCYC to drive a portfolio of digital and AI projects to completion on time and within budget, optimize our software licensing footprint for maximum value, and accelerate the delivery of cutting-edge digital and AI capabilities that support our vital scientific research and overall business growth.

IT Portfolio & Operational Delivery

• Lead the execution of the IT project portfolio, working closely with It team, external partners , and business stakeholders to ensure on-time and high-quality delivery
• Track project progress, manage risks and dependencies, and proactively unblock technical and operational obstacles
• Facilitate regular portfolio status reviews, providing clear and transparent visibility into delivery timelines, resource constraints, and budgets.

License Procurement & Commercial Optimization

• Take absolute accountability for the end-to-end software licensing lifecycle across Bicycle, including sourcing, procurement support, renewals, and ongoing compliance
• Partner with IT leadership, legal, and finance to negotiate enterprise agreements and software contracts, ensuring we secure the best commercial terms, volume discounts, and operational alignment
• Maintain an up-to-date, centralized license inventory, tracking utilization metrics to optimize software spend and prevent 'shelfware'.

AI & Digital Transformation Delivery

• Take delivery accountability for AI, machine learning, and advanced digital initiatives within the IT roadmap, translating strategic AI goals into clear, executable project delivery plans
• Partner with cross-functional teams to deploy AI solutions that accelerate clinical discovery, enhance operational models, and improve productivity
• Manage vendor relationships and external delivery partners specializing in AI technologies to ensure integration standards, timelines, and security guidelines are strictly met

Knowledge & Expertise

• Delivery Frameworks: Strong expertise in IT project delivery methodologies (Agile, Scrum, Waterfall) and portfolio management principles.
• Commercial & Procurement Rigor: Deep understanding of software licensing models (SaaS, enterprise agreements, cloud capacity pricing) and experience leading vendor contract negotiations to secure favourable terms.
• Emerging Technologies: A strong conceptual understanding of modern cloud environments, data integration, and emerging AI technologies/machine learning workflows to guide delivery.
• Data-Driven Insight: The ability to translate system diagnostics, portfolio metrics, and software spend data into actionable recommendations for cost optimization and delivery acceleration.

Job Complexity

• Multi-Track Delivery: Comfortably managing multiple high-priority initiatives simultaneously across distinct domains (e.g., procurement negotiations, infrastructure upgrades, and highly novel AI deployments).
• Problem-Solving: Ability to anticipate resource bottlenecks, commercial risks, and project delivery roadblocks, formulating creative mitigation strategies before they impact the business
• Strategic Impact: Direct impact on BCYC’s fiscal health by actively driving down license waste, while shaping the operational pace of R&D and clinical programs through accelerated AI and IT delivery.

Independence & Leadership

• Autonomy: High degree of independence in managing vendor relationships, leading cross-functional project teams, and executing complex procurement workflows
• Decision-Making: Empowered to make critical delivery and procurement recommendations that directly impact project schedules, vendor selections, and software budgets.
• Stakeholder Management: Exceptional capability to influence, build consensus, and communicate effectively with stakeholders at all levels, from technical engineers to senior executives.

Values & Behaviours

• One Team: Build cohesive, collaborative partnerships across diverse scientific, clinical, and corporate departments to ensure IT deliverables are truly enabling business outcomes.
• We are Adventurous: Challenge traditional delivery methods by pioneering modern project management techniques and encouraging innovative, secure implementations of AI technologies
• Dedicated to our Mission: Take absolute ownership of project and commercial outcomes, remaining fiercely focused on enabling our technology landscape so that our vital science can reach patients.

Qualifications & Experience

• Proven experience in an IT project manager, IT delivery lead, PMO lead, or similar IT operations management role—ideally within a fast-growing biopharmaceutical, life sciences, or technology-driven organization
• Demonstrated track record in managing software procurement, license compliance, and vendor contract negotiations with major software publishers
• Hands-on experience directing or coordinating the delivery of advanced data, analytics, or AI/ML-driven technology projects
• Excellent understanding of IT Service Management (ITSM) best practices (ITIL certification is highly desirable)
• Exceptional organizational, communications, and presentation skills, with a track record of translating complex technical issues into clear executive-level updates
• Bachelor’s degree in computer science, Information Technology, Business Administration, or equivalent practical experience.

• Pension (10% employer contribution)
• Private Medical Insurance (PMI) (including optical and dental cover)
• Health Cash Plan
• Group Life Assurance (4x basic salary)
• Group Income Protection
• Employee Assistance Program (EAP)
• Cycle to Work scheme
• Gym membership (subsidized by Company if on campus, subsidized by PMI if joined elsewhere)
• Time off (28 days annual leave in addition to bank holidays & the option to buy up to 5 additional days annually)
• Competitive reward including annual company bonus
• Employee recognition schemes
• Enhanced parental leave policies
• Flexible working environment
• State-of-the-art campus environment with on campus restaurant and Montessori nursery
• Eligibility for an option grant to subscribe to shares in Bicycle Therapeutics plc.

Bicycle Therapeutics is committed to building a diverse workforce that is representative of the communities we serve. We recognize that diverse and inclusive teams build a stronger and more innovative company. Therefore, all qualified applicants will be considered for employment, and we do not discriminate on the basis of race, religion, colour, gender, sexual orientation, age, disability status, marital status, or veteran status.

Bicycle Therapeutics is committed to building a diverse workforce that is representative of the communities we serve. We recognize that diverse and inclusive teams build a stronger and more innovative company. Therefore, all qualified applicants will be considered for employment, and we do not discriminate on the basis of race, religion, colour, gender, sexual orientation, age, disability status, marital status, or veteran status.