Bicycle Therapeutics is a clinical-stage pharmaceutical company developing a novel class of medicines, referred to as Bicycle® molecules, for diseases that are underserved by existing therapeutics. Bicycle molecules are fully synthetic short peptides constrained with small molecule scaffolds to form two loops that stabilize their structural geometry. This constraint facilitates target binding with high affinity and selectivity, making Bicycle molecules attractive candidates for drug development. The company is evaluating zelenectide pevedotin (formerly BT8009), a Bicycle® Toxin Conjugate (BTC®) targeting Nectin-4, a well-validated tumor antigen; BT5528, a BTC molecule targeting EphA2, a historically undruggable target; and BT7480, a Bicycle Tumor-Targeted Immune Cell Agonist® (Bicycle TICA®) targeting Nectin-4 and agonizing CD137, in company-sponsored clinical trials. Additionally, the company is developing Bicycle® Radio Conjugates (BRC™) for radiopharmaceutical use and, through various partnerships, is exploring the use of Bicycle® technology to develop therapies for diseases beyond oncology.

Bicycle Therapeutics is headquartered in Cambridge, UK, with many key functions and members of its leadership team located in Cambridge, Mass. 

Culture is key and all Bicycle employees actively embrace and role model our company values: 

• We are Adventurous. We believe it’s the way to deliver extraordinary results for our patients.   
• We are Dedicated to our Mission. You can’t change the world if you don’t have determination. 
• We are One Team. We only succeed when we work together.  

We are seeking an experienced and dynamic Senior Director Program Team Leader, to join our innovative biotech company. This pivotal role is integral to the success of one or more multi-indication assets in our portfolio. The Team Leader will spearhead cross-functional program strategy, acting as the central leader and main point of contact for the program team, heads of functions, and governance committees, and has overall accountability for the development of the asset through to commercialization and life-cycle management This position requires a seasoned matrix leader with extensive drug development expertise, strategic vision, and an exemplary cultural fit within our organization.

Drug Development Expertise:

• Lead the strategic direction and execution of one or more asset's integrated nonclinical, translational, clinical, regulatory, CMC, and commercial plans
• Ensure alignment of the program's objectives with the overall company strategy and investment priorities
• Provide expert guidance to the program team to enable advancement of the asset through clinical development
• Stay abreast of competitive landscape to inform and proactively identify alternative strategies

Matrix Leadership Skills:

• Serve as the strategic leader of one or more early-phase program teams, ensuring clear communication and alignment across all functions and levels
• Act as the main point of contact for program strategy between the program team and heads of functions and governance committees, driving strategic decision-making, risk mitigation and issue resolution
• Direct and mentor a cross-functional team of domain area leaders, fostering collaboration and high performance
• Collaborate closely with the program manager to drive program milestones, deliverables, resourcing, and efficiency
• May serve as a key interface to external development partners

Cultural Fit:

• Cultivate a culture of collaboration, transparency, and accountability within the program team and broader organization
• Demonstrate a high sense of urgency and adaptability in a rapidly changing environment
• Build and maintain strong relationships with internal and external stakeholders
• Communicate effectively across all levels of the organization, tailoring messages to diverse audiences
• Exhibit a humble yet strong and decisive executive presence, leading by example and inspiring trust and respect

• Advanced degree (Ph.D., Pharm.D., M.D., M.B.A, or equivalent) in a relevant discipline preferred, but not required
• 10+ years of experience in the biotechnology or pharmaceutical industry, with a track record in drug development; oncology experience preferred
• Proven experience in leading cross-functional, matrixed teams through early-stage and pivotal trial stage
• Exceptional leadership, communication, and interpersonal skills
• Demonstrated ability to operate effectively in a fast-paced, dynamic environment
• Strong strategic thinking and problem-solving abilities

• Flexible working environment
• Competitive reward including annual company bonus
• Medical, dental, and vision insurance for eligible employees and their families with 100% of the premiums covered by the Company
• Health and Dependent Care Flexible Spending Accounts
• 401(k) plan with a 4% Company match and immediate vesting
• Eligibility to accrue up to 23 paid time off days per full year worked, plus the option to buy up to 5 additional days
• Employee assistance program
• Employee recognition schemes
• 10 Company holidays
• Competitive Family Leave Policy
• Eligibility for an option grant to subscribe to shares in Bicycle Therapeutics plc.

All your information will be kept confidential according to EEO guidelines.

Bicycle Therapeutics is committed to building a diverse workforce that is representative of the communities we serve. We recognize that diverse and inclusive teams build a stronger and more innovative company. Therefore, all qualified applicants will be considered for employment, and we do not discriminate on the basis of race, religion, colour, gender, sexual orientation, age, disability status, marital status, or veteran status.