Coherus Biosciences, Inc. is focused on delivering high quality biosimilar therapeutics that will expand the access of important medicines to patients worldwide. Formed in 2010, Coherus has developed a unique, collaborative business model that leverages the leadership team’s deep product development expertise and the expertise of a network of strategic partners to develop therapeutics of the highest quality.  

Research Associate, downstream process development. 

This position requires at least a Bachelors degree in Biochemistry, Biochemical Engineering, or related area accompanied by up to 5 years laboratory experience in protein production, purification, and analysis of therapeutic proteins produced in recombinant organisms.

Knowledge of protein chemistry and protein structure/function analysis is essential. 

ESSENTIAL DUTIES AND RESPONSIBILITIES

• Performs laboratory experiments related to development of robust downstream processes for manufacturing of human therapeutic proteins produced in recombinant mammalian cells and bacteria
• Designs, executes, and analyzes experiments at laboratory scale.
• Develops and characterizes scaled-down models for downstream unit operations.
• Possesses knowledge of and experience with all types of chromatography, centrifugation and filtration techniques.
• Possesses knowledge of and experience with protein analytical techniques such as HPLC, SDS-PAGE, IEF, UV/VIS/fluorescence spectroscopy, etc, and is familiar with scientific and biotechnology industry literature.
• Responsible for accurate laboratory data entry, lab maintenance and upkeep, and report writing. 
• Supports identification and optimization of alternative laboratory methods and/or equipment to improve work efficiency and throughput.

EDUCATION AND EXPERIENCE

• Bachelors or advanced degree in Biochemistry, Biochemical Engineering or other relevant area
• Experience performing a variety of assays including various HPLC methods, capillary electrophoresis, UV/VIS spectroscopy, gel electrophoresis.
• Experience operating downstream equipment such as GE Akta, high pressure homogenizers, Pall and Millipore TFF systems, instrumented reactors for protein refolding studies, etc.
• Understanding and experience with development of scalable process IEX, HIC, Affinity, Mixed Mode, etc, chromatography operations.
• Knowledge of Design of Experiments (DOE).
• Knowledge of cGMP requirements.
• Familiar with Microsoft Windows-type operating systems as well as commonly-used spreadsheet and report writing software applications

DESIRED KEY COMPETENCIES

• Theoretical knowledge and practical experience in protein downstream processing as demonstrated by presentations and/or publication record.
• Participates in solving difficult and complex technical problems.
• Good communication and presentation skills.
• Team player.
• Develops solutions to a variety of complex problems.  Solutions are imaginative, practical and consistent with organization objectives.
• Plans schedules and lab activities to accomplish objectives.
• Ability to track and execute on multiple projects simultaneously.
• Creative, actively participate in idea generation.

WORK ENVIRONMENT

Frequent: Speaking; hearing; sitting; use of hands/fingers; handling or feeling objects, tools or controls; close vision; color vision; peripheral vision; ability to adjust focus

Occasional: Standing; walking indoors; reaching with hands and arms; stooping; kneeling; crouching; lifting and/or move up to 30 lbs

General: Moderate noise level, similar to typical office environment with computers, printers and light traffic

Our Company offers excellent benefits including medical, dental, vision, life, short and long term disability plans, 401k, FSA, vacations, paid holidays and health club reimbursement.