Principal Scientist, Pharmacology

  • _, Boulder, Colorado, United States
  • Full-time

Company Description

Precision therapeutics for genetically defined diseases. Real solutions for real challenges.

Who We Are

Cogent Biosciences is a biotechnology company developing real solutions to treat genetically driven diseases. With a focus on rational drug discovery and development, we are leveraging validated biology to advance precision therapies designed to address the true underlying drivers of disease and provide real hope for patients. Cogent’s lead therapeutic candidate, PLX9486 (expected to be named CGT9486 in the future), is a precision kinase inhibitor designed to selectively and potently inhibit the KIT D816V mutation. This mutation is responsible for driving a rare and serious condition called Systemic Mastocytosis which can severely impact many different tissues and organs in the body. We are also studying PLX9486 to treat advanced gastrointestinal stromal tumors (GIST), which have a strong dependence on oncogenic KIT signaling.

Job Description

We are growing!  This is one of a few roles that will help build out our research team to be located in Colorado.

We are looking for a leader in Pharmacology as we build out our research and discovery teams at Cogent Biosciences. In this opportunity you will be a thought leader our team will look to drive the science as we build out a strategic and robust pipeline.


What You Will Do:

  • Design, implement, and conduct preclinical studies to understand the PK and ADME of novel small molecule drug candidates
  • Plan, design, and initiate studies, analyze data in preparation for final reports
  • Ensure compliance with GLP and other regulatory guidelines
  • Establish in-house expertise in animal models relevant to testing efficacy and safety of human antibodies to generating in vitro and in vivo data that support investigational new drug filings
  • Manage CROs conducting pharmacology related studies
  • Prepare clinical pharmacology documents/sections as required for submission of IND, NDA, and/or MAA


What You Bring:

  • PhD in Pharmacology or related biological sciences and a minimum of 12+ years related experience, or equivalent
  • Experience working on cross functional drug discovery teams
  • Strong knowledge of drug metabolism, ADME concepts and pharmacokinetics, pharmacodynamic and bioanalytical principles
  • Experience working with and managing CROs
  • Expert knowledge of scientific principles and concepts
  • Reputation as emerging leader in field with sustained performance and accomplishment

Additional Information


Our Locations

Cambridge, MA: Our Boston office is located within walking distance of the Alewife T station in Cambridge, MA. Our space includes an open office layout designed for collaboration. Free access is provided for both on-site parking and gym facilities in the building. We are in close proximity to leading academic institutions like MIT and Harvard and to potential pharmaceutical and biotech partners. This unique location allows for a high level of energy and intellectual exchange within and among fast growing early stage companies.

Boulder, CO: We are in the process of building a second location in the fast-growing biopharmaceutical hub in the greater Denver/Boulder corridor.  Our CEO is based full-time in this location, which will serve as the future home of Cogent’s discovery research organization.

Our Offer To You

To attract the very best talent, we offer a generous benefits package that includes competitive pay, performance-based bonus, stock options, insurance coverage (health, dental, life, and disability), unlimited time-off, a 401(k) plan, and commuter/parking benefits.

  • Cogent is an equal opportunity employer
  • Note to agencies – we are not accepting unsolicited resumes from agencies and will not be responsible for fees associated with any such submittals