Bicycle Therapeutics is a clinical-stage pharmaceutical company developing a novel class of medicines, referred to as Bicycle® molecules, for diseases that are underserved by existing therapeutics. Bicycle molecules are fully synthetic short peptides constrained with small molecule scaffolds to form two loops that stabilize their structural geometry. This constraint facilitates target binding with high affinity and selectivity, making Bicycle molecules attractive candidates for drug development. The company is evaluating zelenectide pevedotin (formerly BT8009), a Bicycle® Toxin Conjugate (BTC®) targeting Nectin-4, a well-validated tumor antigen; BT5528, a BTC molecule targeting EphA2, a historically undruggable target; and BT7480, a Bicycle Tumor-Targeted Immune Cell Agonist® (Bicycle TICA®) targeting Nectin-4 and agonizing CD137, in company-sponsored clinical trials. Additionally, the company is developing Bicycle® Radio Conjugates (BRC™) for radiopharmaceutical use and, through various partnerships, is exploring the use of Bicycle® technology to develop therapies for diseases beyond oncology.

Bicycle Therapeutics is headquartered in Cambridge, UK, with many key functions and members of its leadership team located in Cambridge, MA USA

Culture is key and all Bicycle employees actively embrace and role model our company values: 

• We are Adventurous. We believe it’s the way to deliver extraordinary results for our patients.   
• We are Dedicated to our Mission. You can’t change the world if you don’t have determination. 
• We are One Team. We only succeed when we work together.  

The Senior Director, Global Scientific Communications & Publications is a key member of the Medical Affairs leadership team and will be responsible for leading Bicycle’s medical affairs communications strategy and processes, which include the development and execution scientific publications and communications. This role is responsible for cultivating partnerships with cross-functional senior and executive leaders in clinical, program management, corporate communications, investor relations, legal, regulatory, patient advocacy, and commercial to drive a data communication strategy and advance the awareness/understanding of the Bicycle portfolio. This individual will be an experienced people manager, who will lead and be responsible for the company’s publication strategy/review, scientific communications, and medical information processes. Developing effective collaboration and communication processes with internal and external stakeholders will be a key component of this role. This position will report into the VP, Head of Global Medical Affairs.

• Lead the development and execution of annual and long-range publication/scientific communication strategies and tactics to support the Bicycle portfolio
• Provide strategic oversight and improve processes for the development/review of publications (i.e., abstracts, presentations, manuscripts), scientific communication materials, congress materials, and omnichannel amplification activities
• Build and maintain collaborative relationships with senior leadership to ensure alignment of medical communications and publications with corporate strategy and business objectives
• Ensure medical affairs scientific communications are aligned with cross-functional stakeholders to create consistency in scientific messages and narratives
• Assure close but appropriate coordination of medical affairs publication and scientific communication activities with medical affairs functions, clinical, commercial, translational, research, corporate communications, investor relations, and other key Bicycle stakeholders
• Establish Medical Affairs publications, communications, and Medica/Legal/Regulatory (MLR) review standard operating procedures
• Oversee and improve publication strategy and review process with the goal of an integrated publication strategy and plan across Bicycle programs
• Establish and ensure consistent adherence to good publication and authorship practices
• Lead strategic scientific communication planning, including the development of scientific narratives/messages, lexicons, FAQs/backgrounders, and advisory board content
• Provide oversight of the medical information function, including the implementation of a global medical information system and resources to support Bicycle medical information needs
• Conduct ongoing assessments of medical communication and publication capabilities

• Prior biopharmaceutical industry experience is required (10+ years of experience preferred) in medical affairs and oncology publication development
• Advanced degree in health-related field (MD, PhD, or PharmD preferred)
• Strong leadership skills with track-record of building and managing effective teams
• Successful track-record of developing peer-reviewed publications is required
• Advanced understanding of the opportunities and challenges in publications, medical communications, and medical information
• Ability to think strategically and develop scientific publication and communication strategies
• Ability to navigate and succeed in a dynamic, fast-paced environment with a high degree of collaboration and teamwork
• Open, engaging, and transparent with the ability resolve conflict
• Global perspective with ability to work with stakeholders from various cultures and geographies
• Strong business acumen with the ability to prioritize
• Ability to effectively manage scientific communication, publication, and medical information vendors
• Proficiency in clinical data review and interpretation with the ability to simplify scientific messages
• Excellent interpersonal communication skills, written and verbal, and customer-focused approach
• Experience developing and delivering presentations, utilizing PowerPoint slides
• Knowledge of U.S. and ex-U.S. guidelines pertaining to data dissemination and HCP interactions
• Occasional business travel required (~20%)

• Flexible working environment
• Competitive reward including annual company bonus
• Medical, dental, and vision insurance for eligible employees and their families with 100% of the premiums covered by the Company
• Health and Dependent Care Flexible Spending Accounts
• 401(k) plan with a 4% Company match and immediate vesting
• Eligibility to accrue up to 23 paid time off days per full year worked, plus the option to buy up to 5 additional days
• Employee assistance program
• Employee recognition schemes
• 10 Company holidays
• Competitive Family Leave Policy
• Eligibility for an option grant to subscribe to shares in Bicycle Therapeutics plc.

Bicycle Therapeutics is committed to building a diverse workforce that is representative of the communities we serve. We recognize that diverse and inclusive teams build a stronger and more innovative company. Therefore, all qualified applicants will be considered for employment, and we do not discriminate on the basis of race, religion, colour, gender, sexual orientation, age, disability status, marital status, or veteran status.