Senior Bioinformatics Scientist, Translational Medicine

  • 1440 O'Brien Dr, Menlo Park, CA 94025, USA
  • Full-time

Company Description

Zai Lab (NSDAQ: ZLAB) is an innovative, research-based, commercial stage biopharmaceutical company based in China and the U.S. focused on bringing transformative medicines for cancer, autoimmune and infectious diseases to patients in China and around the world.

Headquartered in Shanghai since our founding in 2014, our experienced team has secured partnerships with leading global biopharma companies, generating a broad and late-stage pipeline of innovative drug candidates. Based on our extensive track record of execution and delivering results, Zai Lab has earned the reputation as a trusted partner of choice for global biopharmaceutical companies seeking to not only access the Chinese market but also find a long-term strategic partner for global clinical development. Through these partnerships, Zai Lab has built the strongest late stage oncology portfolio with global first-in-class and/or best-in-class profile, among innovative Chinese biotech companies. We are further supplementing our pipeline with an in-house discovery effort aiming to produce 1-2 global INDs per year.

Zai Lab is rapidly expanding into a fully integrated biopharmaceutical company, discovering, developing, manufacturing and commercializing innovative medicines. To that end, we have built our internal R&D center to advance our discovery pipeline, a strong clinical development and operations team, and our own manufacturing facilities in China. We have also established a highly specialized commercial team to support marketing of our innovative products in China. We believe this integrated approach will provide sustainable competitive advantages for Zai Lab.

Zai Lab was successfully listed on the Nasdaq Stock Market in September 2017 and completed secondary listing on Hong Kong Stock Exchange in September 2020. Zai Lab significantly expanded with several offices across China and U.S. and opened its U.S. headquarters in San Francisco in December 2018. As of June 2021, the Company has a global team of over 1600 employees.

Job Description

We are seeking an innovative computational biologist to help drive Zai Laboratory’s translational efforts. This will include aiding the identification of new targets, developing patient stratification strategies, and helping guide the development of Zai’s clinical pipeline. The successful candidate will have a proven track-record of converting multi-omic datasets into clinically-actionable insights.

 

Responsibilities:

  • Collaborate in leading computational efforts with multi-disciplinary teams, and apply cutting-edge computational approaches to gain maximum insights from large, multi-omic pre-clinical, clinical, and real-world datasets.
  • Collaborate with cancer biologists, immunologists, chemists, statisticians, and develop computational strategies and build tools for target discovery, patient stratification, and development of pharmacodynamic and predictive genomic signatures.
  • Effectively communicate findings at internal and external meetings.

Qualifications

  • Master in bioinformatics, computational biology, statistics, engineering, cancer biology, immunology, genetics, or similar field, with 8+ years of experience.
  • Or Ph.D. in bioinformatics, computational biology, statistics, engineering, cancer biology, immunology, genetics, or similar field, with 2+ years of experience.
  • Extensive experience performing data analysis and visualization using Python and/or R required. A strong background in statistical methods such as data normalization techniques, distribution comparison, enrichment analysis, clustering methods, and multiple hypothesis correction is a must. Ability to lead decisions on which data-science/statistical techniques to apply to answer biologically-driven questions is a requirement.
  • Proven history applying data-science techniques to NGS or other -omics datasets is required, with oncology experience highly desired. Strong preference for candidates practiced in building clinically-actionable prognostic and/or predictive models, especially in the biopharma industry. Previous experience interrogating large public datasets such as TCGA, GTEx, or others a plus.
  • Current capability to initiate and maintain development environments for data-science experiments required, such using as Docker, Jupyter Notebooks and/or R-studio. This includes familiarity with CLI tools for source tracking (e.g. git), data retrieval (e.g. rsync, sftp), at least one database query language (e.g. MySQL). Experience with big data tooling (e.g. Spark) preferred.
  • Excellent independent problem-solving and collaboration skills are a must. Demonstrable ability to clearly communicate computationally-derived results with non-bioinformaticians required. Strong track record of productivity, as evidenced by driving projects forward and robust publications, is highly preferred. Candidates should be enthusiastic, open-minded, and active in scientific development and personal growth.

Additional Information

Disclaimer: This description is not intended to be construed as an exhaustive list of duties, responsibilities, or requirement for the position. All personnel may be required to perform duties outside of their normal responsibilities from time to time, as needed.

All qualified applicants will receive consideration for employment without regard to race, sex, color, religion, sexual orientation, gender identity, national origin, protected veteran status, or based on disability.