Scientist II – Oncology Discovery

  • 1440 O'Brien Dr, Menlo Park, CA 94025, USA
  • Full-time

Company Description

Zai Lab (NSDAQ: ZLAB) is an innovative, research-based, commercial stage biopharmaceutical company based in China and the U.S. focused on bringing transformative medicines for cancer, autoimmune and infectious diseases to patients in China and around the world.

Headquartered in Shanghai since our founding in 2014, our experienced team has secured partnerships with leading global biopharma companies, generating a broad and late-stage pipeline of innovative drug candidates. Based on our extensive track record of execution and delivering results, Zai Lab has earned the reputation as a trusted partner of choice for global biopharmaceutical companies seeking to not only access the Chinese market but also find a long-term strategic partner for global clinical development.  Through these partnerships, Zai Lab has built the strongest late stage oncology portfolio with global first-in-class and/or best-in-class profile, among innovative Chinese biotech companies. We are further supplementing our pipeline with an in-house discovery effort aiming to produce 1-2 global INDs per year.

Zai Lab is rapidly expanding into a fully integrated biopharmaceutical company, discovering, developing, manufacturing and commercializing innovative medicines. To that end, we have built our internal R&D center to advance our discovery pipeline, a strong clinical development and operations team, and our own manufacturing facilities in China. We have also established a highly specialized commercial team to support marketing of our innovative products in China. We believe this integrated approach will provide sustainable competitive advantages for Zai Lab.

Zai Lab was successfully listed on the Nasdaq Stock Market in September 2017 and completed secondary listing on Hong Kong Stock Exchange in September 2020. Zai Lab significantly expanded with several offices across China and U.S. and opened its U.S. headquarters in San Francisco in December 2018. As of June 2021, the Company has a global team of over 1600 employees.

Job Description

The successful candidate will be part of an exciting Biology team focusing on the identification, validation, and advancement of novel therapeutic candidates that are designed to target cancer cells with a precision medicine/synthetic lethal approach.  The candidate will perform hands-on experiments in vitro and ex vivo to identify and validate molecular targets, elucidate mechanisms of action, and determine efficacy of our developing therapeutics in this exciting space.

Major Responsibilities and Duties

  • Design and support molecular biology experiments to interrogate and identify new drug targets and preclinical development of existing targets in our pipeline
  • Hands-on work will include mammalian cell culture, drug/compound screening, and performing various molecular biology-based assays, including CRISPR-based cell line generation, flow cytometry, Western blotting, qRT-PCR, Immunofluorescence, and ELISA.
  • Perform experiments using various in vitro and ex vivo model systems/assays to elucidate molecular and phenotypic effects of target modulation
  • Drive new target discovery efforts by performing and managing genetic (for ex. CRISPR) screens both in-house and with CROs
  • Analyze and present experimental findings to the department and project teams.
  • Work collaboratively on multiple projects concurrently and contribute to activities across functions.

Qualifications

  • PhD or Master’s degree in Biological Sciences/Pharmacology in an oncology-related field. Strong preference for candidates with background in Cell cycle and DNA damage research.
  • At least 0-2 years (PhD) or 8-10 years (M.Sc) of hands-on in vitro experience in cancer biology,
  • Thorough experience in cancer cell/tissue culture and high-throughput assay development are required.
  • Hands-on experience with various in vitro laboratory techniques is required, including Western blotting, qRT-PCR, immunofluorescence, RNAi, CRISPR, and flow cytometry. Strong preference for candidates with CRISPR screening experience
  • Capable of working independently in a fast-paced, team-oriented environment, demonstrating solid and focused organizational skills
  • Confidence in troubleshooting assays, performing and learning new data acquisition and analysis skills are required.
  • Great communication skills and team spirit is a must; ability to communicate results with colleagues and with the biology team at meetings is required.

Additional Information

Diversity Statement:  At Zai Lab we believe a diverse workforce drives our success as a company. We are always working to create an environment where different backgrounds and viewpoints are valued and celebrated.

Zai Lab is an equal opportunity employer. Zai Lab makes employment decisions, including in recruitment and selection, without consideration of race, color, national origin, religion, sex, gender, gender identity or expression, sexual orientation, age, veteran status or disability.

Recruiter Statement: Zai Lab acknowledges that providers may be a valuable resource for identifying and recruiting candidates for employment.  However, we require that all recruiters engage directly with Zai Lab’s Human Resources Team and comply with Zai Lab’s requirements prior to transmitting any resumes/CVs or introducing any candidates to Zai Lab.  Zai Lab’s Human Resource Team is the only function within the Company that can enter contractual relationships with external recruiters and recruiting agencies.