UHN is Canada’s #1 hospital and the world’s #1 publicly funded hospital. With 10 sites and more than 44,000 TeamUHN members, UHN consists of Toronto General Hospital, Toronto Western Hospital, Princess Margaret Cancer Centre, Toronto Rehabilitation Institute, The Michener Institute of Education and West Park Healthcare Centre. As Canada's top research hospital, the scope of biomedical research and complexity of cases at UHN have made it a national and international source for discovery, education and patient care. UHN has the largest hospital-based research program in Canada, with major research in neurosciences, cardiology, transplantation, oncology, surgical innovation, infectious diseases, genomic medicine and rehabilitation medicine. UHN is a research hospital affiliated with the University of Toronto.

UHN’s vision is to build A Healthier World and it’s only because of the talented and dedicated people who work here that we are continually bringing that vision closer to reality.

www.uhn.ca

Union: Non-Union
Number of Vacancies: 1
Site: Princess Margaret Research, MaRS South Tower
Department: Research
Reports to: Principal Investigator
Hours: 37.5 hours per week
Shifts: Day Shift
Status: Permanent Full-time
Closing Date: October 31, 2025

Position Summary
The Scientific Associate III, Coordinator - Biophysical Assays and Hit Validation, will work within an exciting new multidisciplinary international research project which seeks to accelerate the early stages of drug discovery. Reporting to the Co-Director of the UHN Collaborative Centre for Drug Discovery, the Scientific Associate III will coordinate the activities of a research team working on validation hits from ASMS and DEL ultra high throughput sceens, and ensure coordination with collaborating research teams in protein science, novel compound screening technologies, protein interaction characterization, medicinal chemistry, data science, and AI/machine learning. We work closely with academic institutions, pharmaceutical companies, and technology leaders to develop innovative tools and platforms that make biomedical research faster, more collaborative, and more impactful. This open science, milestone-driven program seeks to revolutionize and democratize drug discovery to advance human health.

Apply now and help us redefine how new medicines are discovered!

Duties

• Coordinate hit validation workflows for compounds identified in AS-MS and DEL screening at the Project’s UHN laboratory and international partners.
• Coordinate team discussions and decisions for assay design, execution, and data analysis of protein-ligand interactions assays.
• Ensure consistency and reproducibility of validation experiments across sites, implementing standardized protocols where possible.
• Collaborate with protein production teams to ensure sufficient supplies of high-quality protein samples for follow-up studies.
• Track project progress using databases and project management tools; prepare regular reports, KPIs, and dashboards for leadership, funders, and collaborators.
• Identify technical or logistical bottlenecks in validation workflows and implement solutions to streamline processes.
• Provide scientific input to refine hit triage and selection criteria.
• Facilitate knowledge exchange and communication between internal teams and external collaborating labs.
• Support project planning, risk management, and resource allocation.
• Contribute to lab management activities and ensure adherence to safety standards.

• Ph.D. in Biological or Chemical Sciences is required.
• At minimum, 5 years of related experience is required.
• Experience in protein biochemistry, protein-ligand binding assays, and hit validation in drug discovery.
• Familiarity with AS-MS and/or DEL screening workflows and downstream biophysical/biochemical validation methods is desired.
• Proven track record in collaborative, multi-site research projects.
• Strong analytical, problem-solving, and communication skills.
• Experience with data analysis, reporting, and database management.
• Proficiency with project management (e.g., Jira, Microsoft Project), collaboration (e.g., Slack, Microsoft Teams), and cloud storage tools (e.g., Google Drive, OneDrive).
• Knowledge of health and safety legislation and procedures.
• Willingness and ability to travel to collaborating sites for coordination, training and meetings.

Why join UHN?
In addition to working alongside some of the most talented and inspiring healthcare professionals and researchers in the world, UHN offers a wide range of benefits, programs and perks. It is the comprehensiveness of these offerings that makes it a differentiating factor, allowing you to find value where it matters most to you, now and throughout your career at UHN.

• Competitive offer packages
• Government organization and a member of the Healthcare of Ontario Pension Plan (HOOPP https://hoopp.com/)
• Close access to Transit and UHN shuttle service
• A flexible work environment
• Opportunities for development and promotions within a large organization
• Additional perks (multiple corporate discounts including: travel, restaurants, parking, phone plans, auto insurance discounts, on-site gyms, etc.)

Current UHN employees must have successfully completed their probationary period, have a good employee record along with satisfactory attendance in accordance with UHN's attendance management program, to be eligible for consideration.

All applications must be submitted before the posting close date.

UHN uses email to communicate with selected candidates.  Please ensure you check your email regularly.

Please be advised that a Criminal Record Check may be required of the successful candidate. Should it be determined that any information provided by a candidate be misleading, inaccurate or incorrect, UHN reserves the right to discontinue with the consideration of their application.

UHN is an equal opportunity employer committed to an inclusive recruitment process and workplace. Requests for accommodation can be made at any stage of the recruitment process. Applicants need to make their requirements known.

We thank all applicants for their interest, however, only those selected for further consideration will be contacted.