UHN is Canada’s #1 hospital and the world’s #1 publicly funded hospital. With 10 sites and more than 44,000 TeamUHN members, UHN consists of Toronto General Hospital, Toronto Western Hospital, Princess Margaret Cancer Centre, Toronto Rehabilitation Institute, The Michener Institute of Education and West Park Healthcare Centre. As Canada's top research hospital, the scope of biomedical research and complexity of cases at UHN have made it a national and international source for discovery, education and patient care. UHN has the largest hospital-based research program in Canada, with major research in neurosciences, cardiology, transplantation, oncology, surgical innovation, infectious diseases, genomic medicine and rehabilitation medicine. UHN is a research hospital affiliated with the University of Toronto.

UHN’s vision is to build A Healthier World and it’s only because of the talented and dedicated people who work here that we are continually bringing that vision closer to reality.

www.uhn.ca

Union: Non-Union 
Number of vacancies: 1
Site: TWH – Krembil Discovery Tower
Department: Research
Reports to: Principal Investigator
Hours: 37.5 hours per week
Status: Temporary Full-time
Closing Date: September 19, 2025

Position Summary
Within this position, the Postdoctoral Researcher will pursue research on gene editing of APP and other genes causing familial Alzheimer’s disease. The studies will include the design of components required for prime editing, as well as the development of efficient delivery methods. Apart from correcting disease-causing mutations, the potential of introducing protective mutations will be explored. These strategies will be evaluated on cellular and mouse disease models, in order to determine whether APP editing can reduce pathogenic effects caused by amyloid-beta. In addition to gene editing, the applicant will have the opportunity to be involved in ongoing projects, e.g. development of novel strategies for anti amyloid-beta immunotherapy.

The application should contain a cover letter (maximum 1 page) describing the applicant’s research interests, an updated CV with a list of publications, and copies of diplomas and certificates of higher academic degrees. Please submit as one file. 

Duties:

• Conduct research on gene editing of APP and other genes causing familial Alzheimer’s disease.
• Employ a range of molecular cloning and gene editing techniques.
• Cell biological and histopathological techniques will be used to evaluate the gene therapeutic effects both ex vivo and in vivo. 
• Will be involved in ongoing projects as assigned by the Principal Investigator.

• Completion of a PhD degree, obtained within the previous 5 years, in the field of biomedical sciences.
• Previous experience of basic laboratory techniques, such as immunohistochemistry, western blot and cell culture work.
• Previous experience in molecular cloning.
• Previous experience related to gene editing is desired.
• Previous experience involving laboratory mice is an asset.
• Excellent verbal and written communication skills.
• Excellent organizational and time management skills.
• Ability to produce high quality work and maintain confidentiality.
• Ability to work independently and as part of a team.
• Ability to work well under pressure and use good judgment in assessing difficult situations.

Why join UHN?
In addition to working alongside some of the most talented and inspiring healthcare professionals in the world, UHN offers a wide range of benefits, programs and perks. It is the comprehensiveness of these offerings that makes it a differentiating factor, allowing you to find value where it matters most to you, now and throughout your career at UHN.

• Competitive offer packages
• Government organization and a member of the Healthcare of Ontario Pension Plan (HOOPP https://hoopp.com/)
• Close access to Transit and UHN shuttle service
• A flexible work environment
• Opportunities for development and promotions within a large organization
• Additional perks (multiple corporate discounts including: travel, restaurants, parking, phone plans, auto insurance discounts, on-site gyms, etc.)

Current UHN employees must have successfully completed their probationary period, have a good employee record along with satisfactory attendance in accordance with UHN's attendance management program, to be eligible for consideration.

All applications must be submitted before the posting close date.

UHN uses email to communicate with selected candidates.  Please ensure you check your email regularly.

Please be advised that a Criminal Record Check may be required of the successful candidate. Should it be determined that any information provided by a candidate be misleading, inaccurate or incorrect, UHN reserves the right to discontinue with the consideration of their application.

UHN is an equal opportunity employer committed to an inclusive recruitment process and workplace. Requests for accommodation can be made at any stage of the recruitment process. Applicants need to make their requirements known.

We thank all applicants for their interest, however, only those selected for further consideration will be contacted.