UHN is Canada’s #1 hospital and the world’s #1 publicly funded hospital. With 10 sites and more than 44,000 TeamUHN members, UHN consists of Toronto General Hospital, Toronto Western Hospital, Princess Margaret Cancer Centre, Toronto Rehabilitation Institute, The Michener Institute of Education and West Park Healthcare Centre. As Canada's top research hospital, the scope of biomedical research and complexity of cases at UHN have made it a national and international source for discovery, education and patient care. UHN has the largest hospital-based research program in Canada, with major research in neurosciences, cardiology, transplantation, oncology, surgical innovation, infectious diseases, genomic medicine and rehabilitation medicine. UHN is a research hospital affiliated with the University of Toronto.

UHN’s vision is to build A Healthier World and it’s only because of the talented and dedicated people who work here that we are continually bringing that vision closer to reality.

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Union: Non-Union 
Site: Princess Margaret Cancer Centre 
Department: Surgery Research
Reports to: Principal Investigator
Work Model: On-Site 
Hours: 37.5 hours/week 
Salary: $71,000 to $82,000 (To commensurate with experience and consistent with UHN compensation policy)
Shifts: Day Shifts
Status: Permanent Full-Time
Closing Date: March 27th, 2025

Position Summary:

We are a translational lab focused on gastrointestinal tumour progression and treatment resistance. Our overall goal is to apply new mechanistic insights to better understand cancer progression and develop new therapeutic strategies. 

About 20% of this role will also involve supporting an ongoing clinical trial within Dr. Kazazian’s lab. For this reason, we are looking for a candidate who is eager to expand their skillset to include clinical trials management, or a candidate with relevant experience.  

Duties:

• Applies moderately advanced technical knowledge and skills to perform complex laboratory procedures and experiments
• Perform tissue processing and handling of surgical tissues to support PI's studies
• Biosafety level 2/3 lab work including cell culture and mouse handing
• Standard assays including RT-PCR, flow cytometry, Western blot 
• Preparing samples for next generation sequencing assays 
• Interprets test results and experiments
• Determines next phase of testing/experimentation, identifying appropriate protocol and techniques
• Communicates findings to other lab members and maintains records of experimental data
• Performs animal studies (appropriate education is required)
• Liaises with sponsor for monitoring/audits 
• Exercises significant independent judgement, initiative and decision making, in consultation with investigator, to resolve technical problems (e.g., interpretation of test results, modification of techniques and procedures, etc.)
• Interacts frequently with internal contacts and occasionally with external contacts
• Prepares discussions and status reports on normal business processes in written, verbal or graphical form, as required
• Coordination with UHN biobank, other laboratories, and supporting research students. 
• Laboratory management
• Compiles data from related and/or unrelated sources
• Performs highly complex analyses
• Provides input into decision-making for major purchases
• May modify existing techniques and procedures, as required
• Plans, implements, reviews and coordinates all aspects of data collection and source documentation, as per UHN policy and ICH/GCP guidelines 
• Assist the inter-professional team in performing study specific tasks, including coordinating with OR staff and surgeons for test material labelling and handoff, case report form completion, etc. 
• Collaborates with PI/MD and multidisciplinary health care team in recruitment of study participants (e.g., identifies and screens potential subjects; obtains informed consent; administers questionnaires or other data collection tools) 
• Liaises with sponsor for monitoring/audits 

• Bachelors Degree 
• 6 years related experience 
• Broad expertise in cell and molecular biology methods and the ability to master new techniques and approaches
• Experience with genetically engineered organoids and cell culture, and tissue processing
• Record of productive and rigorous research, including at least one primary publication in a peer-reviewed journal
• Ability to independently plan, conduct, and analyze research
• Excellent written and verbal communication skills, excellent organization, prioritization skills, excellent computer skills, ability to learn quickly and work independently
• Ability to work under pressure with attention to detail
• Ability to perform multiple concurrent tasks 
• Willingness to learn about clinical trials management  
• Experience with clinical trials and/or clinical research is an asset  

Why join UHN? 

In addition to working alongside some of the most talented and inspiring healthcare professionals in the world, UHN offers a wide range of benefits, programs and perks. It is the comprehensiveness of these offerings that makes it a differentiating factor, allowing you to find value where it matters most to you, now and throughout your career at UHN. 

• Competitive offer packages  

• Government organization and a member of the Healthcare of Ontario Pension Plan (HOOPP https://hoopp.com/) 

• Close access to Transit and UHN shuttle service 

• A flexible work environment  

• Opportunities for development and promotions within a large organization 

• Additional perks (multiple corporate discounts including: travel, restaurants, parking, phone plans, auto insurance discounts, on-site gyms, etc.) 

Current UHN employees must have successfully completed their probationary period, have a good employee record along with satisfactory attendance in accordance with UHN's attendance management program, to be eligible for consideration.  

All applications must be submitted before the posting close date.

UHN uses email to communicate with selected candidates.  Please ensure you check your email regularly.

Please be advised that a Criminal Record Check may be required of the successful candidate. Should it be determined that any information provided by a candidate be misleading, inaccurate or incorrect, UHN reserves the right to discontinue with the consideration of their application.

UHN is an equal opportunity employer committed to an inclusive recruitment process and workplace. Requests for accommodation can be made at any stage of the recruitment process. Applicants need to make their requirements known.

We thank all applicants for their interest, however, only those selected for further consideration will be contacted.