ORIC Pharmaceuticals is a clinical stage biopharmaceutical company dedicated to improving patients’ lives by Overcoming Resistance In Cancer. ORIC’s clinical stage product candidates include (1) rinzimetostat, an allosteric inhibitor of the polycomb repressive complex 2 (PRC2) via the EED subunit, being developed for prostate cancer, and (2) enozertinib, a brain penetrant inhibitor that selectively targets EGFR exon 20, HER2 exon 20 and EGFR atypical mutations, being developed across multiple genetically defined cancers. Beyond these two product candidates, ORIC® is also developing multiple precision medicines targeting other hallmark cancer resistance mechanisms. ORIC has offices in South San Francisco and San Diego, California. For more information, please go to www.oricpharma.com, and follow us on X or LinkedIn.

We are seeking an experienced oncology physician to serve as a Medical Director or Senior Medical Director at ORIC Pharmaceuticals. This role provides medical leadership across one or more clinical development programs, with a primary focus on late-stage (registration-enabling) clinical trials. The position plays a critical role in shaping clinical strategy, ensuring scientific rigor, guiding regulatory interactions, and advancing programs from study design through regulatory submission.

The Medical Director will work in close partnership with cross-functional teams including Clinical Operations, Regulatory Affairs, Biostatistics, Safety/Pharmacovigilance, Translational Medicine, and Medical Affairs. The role requires strong strategic thinking, hands-on execution, and the ability to lead effectively in a fast-paced biotech environment.

Clinical and Medical Leadership

• Serve as the medical lead for one or more oncology programs across all phases of development
• Provide medical monitoring oversight for global clinical trials, including Phase 1–3 and registration-enabling studies.
• Act as the primary medical expert for internal teams and external stakeholders
• Represent the company in interactions with investigators, key opinion leaders, advisory boards, and regulatory authorities (e.g., FDA, EMA/CHMP)

Clinical Development Strategy and Execution

• Partner with clinical scientists in the design and execution of clinical protocols, amendments, investigator brochures, study reports, abstracts, and manuscripts
• Partner with biostatistics to define study endpoints, statistical plans, and data analyses
• Ensure scientific rigor, data integrity, and patient-centric decision-making throughout development
• Maintain strong clinical and scientific competitive intelligence through ongoing engagement with the oncology community and key scientific meetings

Cross-Functional Collaboration

• Work closely with Clinical Operations and CROs to support trial execution and operational excellence
• Collaborate with Regulatory Affairs on global regulatory strategy and submissions (e.g., INDs, NDAs, MAA)
• Partner with Safety/Pharmacovigilance to review adverse events, monitor safety signals, and support benefit-risk assessments
• Contribute to biomarker and translational strategies in collaboration with preclinical and translational teams

External Communication and Scientific Contribution

• Support investigator engagement, site training, and advisory board activities
• Contribute to abstracts, manuscripts, posters, and scientific presentations
• Participate in scientific conferences and external meetings as a medical representative of the company

Leadership and Organizational Contribution

• Lead and influence cross-functional teams in a matrixed environment
• Contribute to the overall clinical development strategy and culture of scientific excellence to ensure alignment with ORIC’s values, SOPs, and ethical standards

Education and Training

• MD required
• Board certified or board eligible in Oncology or Hematology/Oncology

Experience

• 5+ years of experience in oncology clinical development, with increasing responsibility; experience in small-mid biotech environment is a plus
• Demonstrated experience leading or contributing to late-phase oncology clinical trials; particularly in prostate cancer is desired
• Strong understanding of global clinical development pathways and regulatory requirements (FDA, EMA, ICH/GCP)
• Familiarity with current medical practice in GU oncology with development experience is a major plus
• Prior experience as a principal investigator or academic clinician is a plus

The anticipated salary range for director level candidates who will work in our San Diego location is between $270,000–$320,000. The final salary offered to a successful candidate will be dependent on several factors that may include, but are not limited to, degree type (MD vs. non-MD), title, type and length of experience within the role, type and length of experience within the industry, education, geography, and other job-related factors.

ORIC Pharmaceuticals, Inc. is an equal opportunity employer. ORIC does not discriminate based on race, color, religion, gender, sexual orientation, gender identity, age, national origin, disability status, protected veteran status, or any other legally protected characteristics.