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Duration: 36+ month

Location: Andover, MA

Top 3 critical skills:

Apply existing protein quantitation workflows using bead and column based immunoaffinity enrichment including the use of liquid handling robotics.

• Run bioanalytical assays under minimal supervision; initiative in method development is expected.

• Independent daily operation, calibration, maintenance, and trouble shooting of multi-dimensional nanoflow liquid chromatography and nanospray triple quadrupole mass spectrometry instrumentation.

• Support analysis of quantitative LC-MS/MS data using relevant bioinformatics and quantitation software.

Minimum education experience required: Bachelors

Job Description:

A rare position is available for a bioanalytical scientist to join a state-of-the-art protein mass spectrometry laboratory lab in Pharmacokinetics Dynamics and Metabolism department. The lab based role will focus on the development of a novel type of sensitive quantitative assay to characterize and quantify the effect of anti-drug antibodies against protein biotherapeutics in the context of unwanted immunogenicity. This position requires expertise in bioanalytical procedures including immunoanalytical workflows, solid background in protein biochemistry, and ideally expertise in triple quadrupole quantitative mass spectrometry. The candidate will participate in all phases of mass spec laboratory operations including the development of sample preparation methods, assay execution, instrument maintenance and data analysis/reporting. We are looking for a scientist passionate about learning and quickly applying new skills to the project needs.

Top 3 critical skills:

Apply
existing protein quantitation workflows using bead and column based
immunoaffinity enrichment including the use of liquid handling robotics.

• Run bioanalytical assays under minimal supervision; initiative in method development is expected.

•Independent daily operation, calibration, maintenance, and trouble shooting of multi-dimensional nanoflow liquid chromatography and nanospray triple quadrupole mass spectrometry instrumentation.

• Support analysis of quantitative LC-MS/MS data using relevant bioinformatics and quantitation software.

Minimum education experience required: Bachelors

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