Guardant Health is a leading precision oncology company focused on helping conquer cancer globally through use of its proprietary tests, vast data sets and advanced analytics. The Guardant Health oncology platform leverages capabilities to drive commercial adoption, improve patient clinical outcomes and lower healthcare costs across all stages of the cancer care continuum. Guardant Health has commercially launched Guardant360®, Guardant360 CDx, Guardant360 TissueNext™, Guardant360 Response™, and GuardantOMNI® tests for advanced stage cancer patients, and Guardant Reveal™ for early-stage cancer patients. The Guardant Health screening portfolio, including the Shield™ test, aims to address the needs of individuals eligible for cancer screening.

Guardant Health has been recognized as one of the Best Places to Work in IT for 2025 by Computerworld!

About the Role: 

The Associate Director of Infrastructure Engineering will oversee the vision, design, implementation, and operations of critical technology solutions for IT Infrastructure to ensure enterprise-wide optimization, security, and compliance. This role involves guiding technological transformations, ensuring the implementation of organizational policies and SLAs, and fostering innovation across platforms while driving efficiencies through automation. The successful candidate will manage teams responsible for maintaining high network security, system reliability, and disaster recovery standards, while aligning with industry standards such as NIST, ISO 27001, HIPAA, and others. 

Essential Duties and Responsibilities: 

Technological Transformation and Optimization: 

• Oversee the technological roadmap and transformation strategies, ensuring alignment with the organization’s strategic goals. 

• Foster innovation by developing a culture of continuous improvement, challenging status quo and rapid prototyping to develop scalable solutions 

• Adoption of emerging technologies while demonstrating business value. 

• Optimizing platforms across the enterprise and driving system efficiencies through automation and process streamlining. 

• Ensure adherence to enterprise-wide security and compliance protocols. 

Leadership and Strategy: 

• Create vision for next-generation IT infrastructure, with migration plans to best-in-class architecture to support business scalability goals. 

• Lead cross-functional teams responsible for integrating and managing technology solutions such as Palo Alto Networks Prisma, Cisco ICE, Ring Central, Juniper MIST, Simpplr, and CrowdStrike. 

• Supervise technology stack overhauls, including on-premise and cloud infrastructure, ensuring scalability, security, and resilience. 

• Guide the creation and execution of organizational policies and SLAs, focusing on system reliability, disaster recovery, and process efficiency. 

• Vendor management and contract negotiation. 

Compliance and Security: 

• Develop, preserve, and execute Policies and Standards ensuring compliance with relevant regulatory frameworks (e.g., GDPR, SOX). 

• Ensure all systems are secure, compliant, and regularly audited for vulnerabilities, optimizing security across the network infrastructure. 

• Lead the disaster recovery strategy, ensuring business continuity through effective endpoint data management, backup strategies, and restoration processes. 

• Implement and maintain all Services under remit based on Secure by Design principles. 

• Support Incident Response team as infrastructure SME. 

Collaboration and Stakeholder Management: 

• Collaborate with senior leadership to align infrastructure goals with business needs. Minimize or avoid disruption to business operations during planned infrastructure changes. 

• Work across technical domains to enable productivity for software development teams, including support for application hosting and infrastructure-as-code solutions. 

• Engage with vendors, ensuring cost-effective solutions and continuous technological improvements, optimizing shared infrastructure where appropriate. 

• Mentor and lead engineering teams to drive performance, engagement, and professional development. 

• Contribute thought leadership to the development of technology strategy and solutions across multiple technical and business functions. 

• Bachelor's degree in Computer Science, Information Systems, or a related field.
• 10+ years of experience in Infrastructure Engineering or related fields, with at least 5 years in a leadership role.
• Strong domain specific expertise:
  • Implementing and managing network infrastructure, cloud infrastructure, and disaster recovery solutions.
  • Managing data center operations for virtual and data systems.
  • Managing DevOps and AWS cloud technologies and operations.
  • Leading transformation to Software-defined / Zero-trust architectures.
  • Driving automation and process efficiencies in complex enterprise environments.
• Experience in implementing security best practices supporting technology based on strong engineering rigor.
• Familiarity with industry standards such as NIST, ISO 27001, HIPAA, SOX, CCPA, and GDPR. Preference for healthcare/biotech industry experience.
• Familiarity with support for High Performance Computing technologies and operations.
• Experience of integrations with external systems, eg through joint ventures, partnerships or M&A
• Experience of operating in a high-growth public company, while maintaining quality and scalability in solution implementations.

Hybrid Work Model: At Guardant Health, we have defined days for in-person/onsite collaboration and work-from-home days for individual-focused time. All U.S. employees who live within 50 miles of a Guardant facility will be required to be onsite on Mondays, Tuesdays, and Thursdays. We have found aligning our scheduled in-office days allows our teams to do the best work and creates the focused thinking time our innovative work requires. At Guardant, our work model has created flexibility for better work-life balance while keeping teams connected to advance our science for our patients.

For positions based in Palo Alto, CA or Redwood City, CA, the base salary range for this full-time position is $163,200 to $220,300. The range does not include benefits, and if applicable, bonus, commission, or equity.

Within the range, individual pay is determined by work location and additional factors, including, but not limited to, job-related skills, experience, and relevant education or training. If you are selected to move forward, the recruiting team will provide details specific to the factors above.

Employee may be required to lift routine office supplies and use office equipment. Majority of the work is performed in a desk/office environment; however, there may be exposure to high noise levels, fumes, and biohazard material in the laboratory environment. Ability to sit for extended periods of time.

Guardant Health is committed to providing reasonable accommodations in our hiring processes for candidates with disabilities, long-term conditions, mental health conditions, or sincerely held religious beliefs. If you need support, please reach out to [email protected]

Guardant Health is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, or protected veteran status and will not be discriminated against on the basis of disability.

All your information will be kept confidential according to EEO guidelines.

To learn more about the information collected when you apply for a position at Guardant Health, Inc. and how it is used, please review our Privacy Notice for Job Applicants.

Please visit our career page at: http://www.guardanthealth.com/jobs/

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