Summer Intern - Protein Chemistry

  • 111 Oyster Point Blvd, South San Francisco, CA 94080, USA
  • Full-time

Company Description

Five Prime Therapeutics, Inc. (NASDAQ: FPRX) is a publicly traded, clinical-stage biotechnology company focused on discovering and developing innovative immuno-oncology protein therapeutics to improve the lives of patients with serious diseases.  

We have an industry-leading and differentiated drug discovery platform.  Our comprehensive proprietary libraries of the extracellular proteome, differentiated screening capabilities and protein therapeutic generation and engineering capabilities comprise a unique and powerful IND engine that will continue to generate important development programs.  This uniquely positions us to discover novel pathways and targets in immuno-oncology.  

Our success with our drug discovery platform has led to a pipeline that is on track to more than double to five development programs in clinical trials across multiple indications in 2018.  We also have several undisclosed research programs at different points of the target validation and molecule generation phases that have the potential to yield our next wave of development-stage therapeutic biologics.  And we continue to fuel this process at the earliest stages with new screens planned this year.

FivePrime is committed to innovation and outstanding science, values that are reflected in our people and our products. Discover more about FivePrime at

Job Description

The Protein Chemistry group would like a summer intern interested acquiring hands on experience in cell biology, protein chemistry, and applied robotics. The position will entail assisting in weekly high-throughput robotic transfection of approximately 2000 unique proteins per week at therapeutically relevant amounts for use in multiple discovery assays. The position will additionally offer the opportunity to participate in the validation and implementation of new cDNA libraries currently in development. The intern will learn and apply aseptic cell culture technique, transient transfection, and measurement of recombinant proteins expression. The chosen candidate will acquire significant experience in a fast-paced working environment focused on biopharmaceutical development.

Essential Functions and Duties

  • Assist in robotic production of up to 5000 different full-length, biologically active proteins for use in cell-based discovery assays.
  • Work with manager to safely and consistently operate multiple robotic liquid handling platforms.
  • Assist in testing of new methodology for transfection and expression of recombinant proteins.


  • Major in Biological Sciences (preferred) or Chemistry
  • At least two years of college coursework in biological or chemical science
  • The candidate should be highly organized, detail-oriented, and methodical
  • Wet lab Experience is a plus
  • Programming or engineering experience is a plus

Additional Information

At FivePrime, we believe a diverse workforce drives our success as a company. We are always working to create an environment where different backgrounds and viewpoints are valued and celebrated.

FivePrime is an equal opportunity employer. FivePrime makes employment decisions, including in recruitment and selection, without consideration of race, color, national origin, religion, sex, gender, gender identity or expression, sexual orientation, age, veteran status or disability.Please call or reply with any comments.


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