Summer Intern, Molecular Biology

  • 111 Oyster Point Blvd, South San Francisco, CA 94080, USA
  • Intern

Company Description

Five Prime Therapeutics, Inc. (NASDAQ: FPRX) is a publicly traded, clinical-stage biotechnology company focused on discovering and developing innovative immuno-oncology protein therapeutics to improve the lives of patients with serious diseases.  

We have an industry-leading and differentiated drug discovery platform.  Our comprehensive proprietary libraries of the extracellular proteome, differentiated screening capabilities and protein therapeutic generation and engineering capabilities comprise a unique and powerful IND engine that will continue to generate important development programs.  This uniquely positions us to discover novel pathways and targets in immuno-oncology.  

Our success with our drug discovery platform has led to a pipeline that is on track to more than double to five development programs in clinical trials across multiple indications in 2018.  We also have several undisclosed research programs at different points of the target validation and molecule generation phases that have the potential to yield our next wave of development-stage therapeutic biologics.  And we continue to fuel this process at the earliest stages with new screens planned this year.

FivePrime is committed to innovation and outstanding science, values that are reflected in our people and our products. Discover more about FivePrime at

Job Description

In support of target discovery teams, our intern will assist in optimizing minicircle DNA production methods. The intern will learn hypothesis driven approach to solve biological and technical problems. He or she will learn how to design experiments, how to analyze data, and how to make data driven decisions for further improvement. By doing so, the intern will help us to develop and implement a protocol that will enable efficient and consistent production of high quality minicircle DNAs. The intern will learn about the purpose and uses of DNA minicircles, and focus on optimizing methods to produce the minicircles. The intern will help set up bacterial cultures, purify DNA, run quality control assays, and track samples using in-house databases. Importantly, the intern will assist us in understanding parameters that impact minicircle production, such as vector elements, component cells, transformation methods, and DNA prep method.


  • Major in Biological Sciences (preferred)
  • At least two years of college coursework in biological or chemical science
  • Ability to communicate and collaborate in a team environment
  • Accurate record keeping is necessary
  • Attention to detail
  • Good organizational skills
  • Experience with aseptic technique is preferred
  • Previous experience in molecular biology is preferred

Additional Information

At FivePrime, we believe a diverse workforce drives our success as a company. We are always working to create an environment where different backgrounds and viewpoints are valued and celebrated.

FivePrime is an equal opportunity employer. FivePrime makes employment decisions, including in recruitment and selection, without consideration of race, color, national origin, religion, sex, gender, gender identity or expression, sexual orientation, age, veteran status or disability.Please call or reply with any comments.


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