Summer Intern - Antibody Engineering & Technology

  • 111 Oyster Point Blvd, South San Francisco, CA 94080, USA
  • Intern

Company Description

Five Prime Therapeutics, Inc. (NASDAQ: FPRX) is a publicly traded, clinical-stage biotechnology company focused on discovering and developing innovative immuno-oncology protein therapeutics to improve the lives of patients with serious diseases.  

We have an industry-leading and differentiated drug discovery platform.  Our comprehensive proprietary libraries of the extracellular proteome, differentiated screening capabilities and protein therapeutic generation and engineering capabilities comprise a unique and powerful IND engine that will continue to generate important development programs.  This uniquely positions us to discover novel pathways and targets in immuno-oncology.  

Our success with our drug discovery platform has led to a pipeline that is on track to more than double to five development programs in clinical trials across multiple indications in 2018.  We also have several undisclosed research programs at different points of the target validation and molecule generation phases that have the potential to yield our next wave of development-stage therapeutic biologics.  And we continue to fuel this process at the earliest stages with new screens planned this year.

FivePrime is committed to innovation and outstanding science, values that are reflected in our people and our products. Discover more about FivePrime at

Job Description

The AET Group is looking for a summer intern to help with next generation sequencing (NGS) platform implementation. The intern will help scientists establish the technology in-house for the high through-put sequencing of immune repertoires from different animal models for the discovery of therapeutic and tool antibodies. The intern will compare the workflow and efficiency of antibody discovery using NGS with B-cell cloning. In addition, the intern will be using the scientific method to optimize the workflow for NGS and B-cell cloning. Through this project the intern will develop a fundamental understanding and basic lab skills that are required in the antibody discovery process. The set of skills will include: aseptic techniques for handling and preparing recombinant and primary cell cultures; molecular biology techniques to enable construction of recombinant DNA plasmids and NGS library preparation; and cell labeling, analysis and sorting via FACS.


  • An individual with aseptic technique and molecular biology experience is highly desired
  • A background in immunology and/or antibody experience is desired
  • Experience with immune repertoire sequencing is a plus
  • The individual should be motivated, detail-oriented, well organized and possess good communication skills

Additional Information

At FivePrime, we believe a diverse workforce drives our success as a company. We are always working to create an environment where different backgrounds and viewpoints are valued and celebrated.

FivePrime is an equal opportunity employer. FivePrime makes employment decisions, including in recruitment and selection, without consideration of race, color, national origin, religion, sex, gender, gender identity or expression, sexual orientation, age, veteran status or disability.Please call or reply with any comments.


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