Director, Human Resources

  • 111 Oyster Point Blvd, South San Francisco, CA 94080, USA
  • Full-time

Company Description

Five Prime Therapeutics, Inc. (NASDAQ: FPRX) is a publicly traded, clinical-stage biotechnology company focused on discovering and developing innovative immuno-oncology protein therapeutics to improve the lives of patients with serious diseases.  

We have an industry-leading and differentiated drug discovery platform.  Our comprehensive proprietary libraries of the extracellular proteome, differentiated screening capabilities and protein therapeutic generation and engineering capabilities comprise a unique and powerful IND engine that will continue to generate important development programs.  This uniquely positions us to discover novel pathways and targets in immuno-oncology.  

Our success with our drug discovery platform has led to a pipeline that is on track to more than double to five development programs in clinical trials across multiple indications in 2018.  We also have several undisclosed research programs at different points of the target validation and molecule generation phases that have the potential to yield our next wave of development-stage therapeutic biologics.  And we continue to fuel this process at the earliest stages with new screens planned this year.

FivePrime is committed to innovation and outstanding science, values that are reflected in our people and our products. Discover more about FivePrime at

Job Description

The Human Resources Director will serve as the primary human resources business partner for 225 FivePrime employees and will work on a broad range of business activities such as culture, employee engagement, organizational design / development, change management, employee development, performance management and employee relations to enable a high-performing workforce and achievement of Five Prime’s goals.  This position reports to the SVP of Human Resources.

Essential Functions:

  • Gain an in-depth understanding of the business while building strong and effective relationships with senior leaders, managers and employees to become a trusted and respected partner and coach
  • Act as strategic business partner focused on a broad range of business activities

  • Contribute to the design and implementation of HR programs and initiatives such as succession planning, leadership development, annual compensation planning, individual development plans, and engagement initiatives

  • Facilitate and coach business leaders and their leadership teams regarding employee relation issues. 

  • Partner with the Talent Acquisition team and hiring managers to ensure we bring in top talent

  • Partner with the HR Operations team on the delivery of value added policies/ processes/ solutions to support our employees and continuing business success.

  • Partner with the SVP of HR on strategic projects and initiatives

  • Consult in close collaboration with Legal and Finance on ensuring compliance and adherence to applicable FivePrime policies.

  • Other projects/ duties as needed.


  • Bachelor’s degree required, advanced degree is a plus, prefer prior experience in biotechnology industry supporting a Research and Development organization

  • Minimum of 12 years of progressive HR experience, with at least three years of experience operating as a senior HRBP in a complex and rapidly growing environment

  • Strong business acumen and critical thinking

  • Experience in organizational development and design, change leadership, employee relations, talent management and performance management

  • Role model for FivePrime Values with proven high integrity

  • Excellent interpersonal communication, and presentation skills

  • Proven ability to influence and collaborate cross-functionally to solve problems and implement proactive solutions

  • Ability to deal with ambiguity and high change agility

  • Energetic, resourceful with strong customer service orientation

  • Strong team player who quickly establishes trust with employees at all levels of the organization


Additional Information

At FivePrime, we believe a diverse workforce drives our success as a company. We are always working to create an environment where different backgrounds and viewpoints are valued and celebrated.

FivePrime is an equal opportunity employer. FivePrime makes employment decisions, including in recruitment and selection, without consideration of race, color, national origin, religion, sex, gender, gender identity or expression, sexual orientation, age, veteran status or disability.Please call or reply with any comments.


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