Research Associate I, Cell Genomics Engineering
- 111 Oyster Point Blvd, South San Francisco, CA 94080, USA
Five Prime Therapeutics, Inc. (NASDAQ: FPRX) is a publicly traded, clinical-stage biotechnology company focused on discovering and developing innovative immuno-oncology protein therapeutics to improve the lives of patients with serious diseases. We have an industry-leading and differentiated drug discovery platform. Our comprehensive proprietary libraries of the extracellular proteome, differentiated screening capabilities and protein therapeutic generation and engineering capabilities comprise a unique and powerful IND engine that will continue to generate important development programs. This uniquely positions us to discover novel pathways and targets in immuno-oncology. Our success with our drug discovery platform has led to a pipeline that is on track to more than double to five development programs in clinical trials across multiple indications in 2018. We also have several undisclosed research programs at different points of the target validation and molecule generation phases that have the potential to yield our next wave of development-stage therapeutic biologics. And we continue to fuel this process at the earliest stages with new screens planned this year.
Five Prime is committed to innovation and outstanding science to develop effective new drugs for the treatment of severe diseases. We value our culture of openness, collaboration and productivity. The company is in a strong financial position and has an effective executive team and Board of Directors. Discover more about FivePrime at www.fiveprime.com.
We are seeking a highly motivated Research Associate II to join Genomics Cell Engineering group in Biotherapeutics Department. The successful candidate will join our team to develop engineered cells and methods to accelerate development of novel antibody and protein therapeutics and Five Prime. This position reports to Scientist III, Genomics Cell Engineering.
Work on cell line engineering projects i.e. developing engineered cell lines for in vitro cell-based assay, implementing engineered cell lines for protein expression, developing knock-out or knock-in cell lines
Perform day-to-day laboratory bench work including molecular cloning, cell culture, transfection, limiting dilution, screening cell lines, freezing, thawing cell lines
Perform assays to characterize and validate the cell lines and methods
Document experimental activities and data analysis in electronic notebook
Review experimental data, discuss scientific findings with scientists and team members, troubleshoot experiments and suggest improvements
Present project progress in one-on-one and team meetings
Other projects and duties as needed
B.S or M.S. in biochemistry, molecular biology, cell biology, biochemical engineering, or related discipline with 5+ years of lab experience
Experience in mammalian cell culture with excellent aseptic technique
Experience and/or good understanding of cell engineering and genome editing technology i.e. CRISPR/Cas9, transposases, recombinases
Experience with relevant technique/system is a plus i.e. molecular biology technique, transfection, qPCR, RT-qPCR, flow cytometry and cell sorting, recombinant protein expression system
Ability to solve complex problems independently via critical and innovative thinking
Attention to detail with good organizational and recording keeping skills
Eager to learn and collaborate well with others
Excellent written and interpersonal communication skills
- Diligent, strong growth mindset with positive “can-do” attitude towards assigned tasks
At FivePrime, we believe a diverse workforce drives our success as a company. We are always working to create an environment where different backgrounds and viewpoints are valued and celebrated.
FivePrime is an equal opportunity employer. FivePrime makes employment decisions, including in recruitment and selection, without consideration of race, color, national origin, religion, sex, gender, gender identity or expression, sexual orientation, age, veteran status or disability.Please call or reply with any comments.
All your information will be kept confidential according to EEO guidelines.