Senior Research Engineer

  • 111 Oyster Point Blvd, South San Francisco, CA 94080, USA
  • Full-time

Company Description

Five Prime Therapeutics, Inc. (NASDAQ: FPRX) is a biotechnology company discovering and developing innovative immuno-oncology protein therapeutics.  FivePrime has a differentiated discovery platform and capabilities that is fueling a growing portfolio of development candidates.

Our pipeline includes:

  • Cabiralizumab (FPA008), an anti-CSF-1R antibody currently in development in a Phase 2 trial in pigmented villonodular synovitis (PVNS) and a Phase 2 trial in second-line pancreatic cancer 
  • FPA144, an anti-FGFR2b antibody currently in a Phase 1/3 clinical trial in FGFR2b over-expressing gastric cancer
  • FPA150, an anti-B7H4 antibody will enter Phase 1 clinical development in the first half of 2018
  • FPT155, a CD80 fusion protein, which is in IND-enabling studies

We have entered into strategic discovery and development collaborations with leading pharmaceutical and biotech companies, including Bristol-Myers Squibb, GSK, UCB and Zai Labs.

FivePrime is committed to innovation and outstanding science, values that are reflected in our people and our products. Discover more about FivePrime at

Job Description

We are currently seeking a talented and enthusiastic Scientist in the Systems Engineering group at Five Prime Therapeutics. This is an exciting opportunity to design, build, and support exceptional technologies that enable cutting edge science and empower researchers to accelerate the discovery and development of novel protein and antibody drugs.


Lead innovation, technology development projects:

  • Explore, prototype, develop/procure new enabling technologies (robotic automation, microfluidics, tissue imaging, bio-analytical sensors, etc.) for high throughput biologics experimentation.
  • Collaborate with researchers to adapt existing or develop new cell/tissue based and bio-physical assays for miniaturization and ultra-high throughput experimentation.

Support operations in a state-of-the-art robotics and microfluidics lab:

  • Partner with automation engineers, scientists, and research associates to design and develop protocols to conduct biological and bio-chemical experiments on automation platforms.

  • Integrate and support analytical instruments such as plate readers, high content imagers, PCR instruments, multiplexed assay instruments, etc. in automated workflows.

  • Collaborate with researchers and the data integration team to develop protocols and informatics workflows that automate large-scale sample tracking, data capture and analysis, and visualization.

  • Other projects when assigned 


  • Ph.D. in Biomedical engineering, Bio Engineering, Chemical Engineering or related discipline with 0-2 years relevant work experience.

  • Experience with cell culture processes and cell based assays.

  • Experience with tissue imaging, high content imaging and image analysis workflows.

  • Familiarity with microfluidic technologies such as droplet microfluidics for biologic applications.

  • Familiarity with analytical instruments such as multi-mode plate readers, high content imagers, PCR equipment, tissue imagers, and NGS.

  • Familiarity with writing scripts in a language like Perl, Python or JavaScript or programming in a language like C#, C++ or Java.

  • Effective communication skills and well-developed interpersonal skills.

  • Intrinsically motivated, with a passion for technology development, innovation, and enabling outstanding Science.

Additional Information

At FivePrime, we believe a diverse workforce drives our success as a company. We are always working to create an environment where different backgrounds and viewpoints are valued and celebrated.

FivePrime is an equal opportunity employer. FivePrime makes employment decisions, including in recruitment and selection, without consideration of race, color, national origin, religion, sex, gender, gender identity or expression, sexual orientation, age, veteran status or disability.Please call or reply with any comments.

All your information will be kept confidential according to EEO guidelines.

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