LC/MS Protein Characterization Scientist

  • Full-time

Company Description

Eurofins Scientific is an international life sciences company, providing a unique range of analytical testing services to clients across multiple industries, to make life and our environment safer, healthier and more sustainable. From the food you eat, to the water you drink, to the medicines you rely on, Eurofins works with the biggest companies in the world to ensure the products they supply are safe, their ingredients are authentic and labelling is accurate. Eurofins believes it is a global leader in food, environmental, pharmaceutical and cosmetics products testing and in agroscience CRO services. It is also one of the global independent market leaders in certain testing and laboratory services for genomics, discovery pharmacology, forensics, CDMO, advanced material sciences and in the support of clinical studies.

In over just 30 years, Eurofins has grown from one laboratory in Nantes, France to over 47,000 staff across a network of more than 900 independent companies in over 50 countries and operating more than 800 laboratories. Eurofins offers a portfolio of over 200,000 analytical methods to evaluate the safety, identity, composition, authenticity, origin, traceability and purity of biological substances and products, as well as providing innovative clinical diagnostic testing services, as one of the leading global emerging players in specialised clinical diagnostics testing.

 In 2019, Eurofins generated total revenues of EUR € 4.56 billion, and has been among the best performing stocks in Europe over the past 20 years.

Job Description

  • Familiar with protein structure and chemistry; experience handling proteins in a laboratory setting
  • Develop LCMS method for peptide mapping and disulfide mapping of proteins, antibodies and antibody-drug conjugates
  • Versed in proteolytic digestion procedures
  • Develop methods to identify the site occupancy of drugs in protein drug conjugates
  • Develop methods to identify post-translational modifications including deamidation and oxidation sites in proteins.
  • Develop methods to characterize glycoforms in glycoproteins
  • Develop mass spectroscopy methods for the determination of intact mass for proteins, peptides, and small molecules
  • Familiar with MSMS fragmentation of small molecules and peptides
  • Skilled at converting HPLC methods to LCMS compatible methods
  • Skilled in the operation of Waters QToF instruments and software (MassLynx)
  • Skilled at structural elucidation using accurate mass data
  • Skilled at developing HPLC and UPLC methods

Qualifications

  • Applies GMP/GLP in all areas of responsibility, as appropriate
  • Applies the highest quality standard in all areas of responsibility
  • Demonstrates and promotes the company vision
  • Demonstrates strong client service skills, teamwork, and collaboration
  • Proactively plans and multitasks to maximize productivity
  • Meets all quality and productivity metrics and demonstrates strong teamwork and collaboration
  • Test serum samples from clinical drug development studies to determine drug level and anti-drug antibodies (ADA) in immunoassays to support high priority biological and vaccine programs
  • Work according to established Standard Operating Procedures (SOPs) and regulatory guidance
  • Maintain accurate records of ongoing projects in adherence with documentation standards
  • Assist in generation and review of reports and contribute to trouble shooting efforts
  • Work in a structured environment under limited to moderate supervision
  • Communicates effectively with client staff members
  • Conducts all activities in a safe and efficient manner

Additional Information

What we Offer:

  • Excellent full time benefits including comprehensive medical coverage, dental, and vision options

  • Life and disability insurance

  • 401(k) with company match

  • Paid vacation and holidays

Eurofins is a M/F, Disabled, and Veteran Equal Employment Opportunity and Affirmative Action employer.

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