Company Overview

At Corbus we are committed to connecting innovation to purpose. We are bringing new insights to the fields of biology, with the aim of improving outcomes for cancer patients. We are committed to the concept of precision medicine, even in the field of immune oncology. Taking advantage of the evolution of multi-omic platforms to create deeper resolution as to the mechanism of action of our emerging medicines. We are creating a complementary pipeline balanced for both risk and speed.

Corbus is a precision oncology company committed to helping people defeat serious illness by bringing innovative scientific approaches to well understood biological pathways. Corbus’ internal development pipeline includes CRB-701, a next generation antibody drug conjugate (ADC) that targets the expression of Nectin 4-on cancer cells to release a cytotoxic payload and CRB-601, and anti-integrin monoclonal antibody which blocks the activation of TGFβ expressed on cancer cells. Corbus is headquartered in Norwood, Massachusetts. For more information on Corbus, visit corbuspharma.com. Connect with us on Twitter, LinkedIn and Facebook.

Corbus Culture

Our passion. Our purpose. At Corbus, it starts at our core.

We look for committed talent. Our people are brilliant, they break barriers and their contributions are not defined by title or role. Corbus recognizes that it is our diversity of experiences that make us valuable and Corbus welcomes transformative ideas from anyone. Corbus is a special place to share ideas and grow. We create flexibility and the opportunity to excel in their professional journey. We provide a welcoming space where collaboration, mentorship and diversity are encouraged. We come together, like no other, to elevate each other and focus on what’s best for patients.

Corbus is a close-knit team of high-achieving, innovative, creative and, above all else, passionate employees. We hire for personality as well as for skill.  At Corbus, we take pride in our “family” atmosphere where each person’s contribution is vital to our success. Corbus believes that fun along the way is also part of the equation that makes for high performing teams. As a Corbus employee, you are empowered to think creatively and be proactive in your approach. There is no place for politics or red tape here.

What We Offer

Corbus offers a fast-paced, entrepreneurial, team-focused work environment. We also offer a top-notch benefits package and work/life integration. Being part of the team allows you to become part of a growing organization that supports professional development while working together to meet the company goals.

Corbus Pharmaceuticals Holdings, Inc. is an equal opportunity employer.

Corbus is searching for a dynamic scientific lead to join our biologics team. You will be engaged in translational research to define mechanism of action to guide clinical development of Corbus’s portfolio of anti-tumor agents, as well as provide hands-on support to the discovery and early preclinical development of therapeutic antibodies.  You will have an opportunity to design and lead multiple high priority projects through the selection of development candidate(s) and generate to new pipeline initiatives.

This represents an excellent opportunity to work with an enthusiastic and talented team of highly skilled scientists in a matrixed and collaborative environment. Corbus is developing therapeutic antibodies in the area of immunotherapy and targeted payload (ADC) delivery. Your role requires in-depth technical and hands-on knowledge of cell-based assays to elucidate factors driving tumor sensitivity and resistance and evaluating biomarkers of response in order to guide patient selection. You will also lead prioritization of translational pharmacology models to guide clinical positioning. You will drive the advancement of our growing pipeline programs by working closely with the scientific leadership team to validate novel targets with proof-of-concept in vitro and in vivo models, and collaborate with the antibody discovery team to scale assays in support of broad candidate screening. 

The successful candidate will have excellent organizational and oral/written communication skills, the ability to design and troubleshoot experiments independently, and the organizational skillset to manage multiple projects simultaneously on tight timelines. A proven leadership and ability to manage upwards is a requirement.

Key Responsibilities and Opportunities:

• Manage the design, coordination, and implementation of key research studies aimed at lead candidate selection, animal proof-of concept, pharmacology, mechanism of action, and other innovative studies. 
• Lead efforts to refine and execute robust in vitro cell based assays to establish the activity and mechanism of action of therapeutic antibody candidates.
• Design pathway driven approaches, including genomic/transcriptomic strategies, to define mechanism of action and identify biomarkers of response or resistance
• Partner with the Translational biology team to select relevant cell-based models in support of candidate discovery and in vivo animal models.
• Leverage a network of external CROs and Scientific Advisors to ensure efficient and effective execution of critical research projects
• Contribute to and ensure the quality of both invitro and In vivo pharmacology study reports, data reviews and interpretations, presentations, scientific publications and recommendations to development teams and management.
• Measuring target engagement and pharmacodynamic biomarkers reliably and quantifiably to advise clinical decisions for selecting therapeutically relevant doses and schedules.
• Understanding of key cancer pathway interactions, feedback mechanisms, and features of tumor microenvironment in clinical samples to guide rational drug combinations.
• Lead new target nomination and validation efforts to help design project strategy, experimentation, analysis, and interpretation of experiment
• Ability to critically design, evaluate, summarize, and interpret data, and effectively communicate scientific concepts, findings, and interpretations at group, project team and departmental research meetings
• Contribute to the writing of technical and regulatory documents, patents, scientific manuscripts, etc.
• Evaluate and analyze published scientific and patent literature outside of their immediate area of expertise and apply this understanding to drive innovation

Requirements

• Ph.D. in Tumor Biology, Immunology, Pharmacology or related scientific discipline.
• 7+ years of experience (after post doctoral) in discovery and development of antibody based therapeutics is essential in oncology directed programs
• Deep understanding of cellular and molecular mechanisms of tumorigenesis and tumor resistance mechanisms
• Experience in developing an antibody based immunotherapy and/or antibody drug conjugate from early discovery to clinic is highly preferred.
• Demonstrated impact in advancing candidates through translational research and preclinical development.
• Ability to drive, manage, execute and deliver results for complex multi-functional projects.
• Experience in planning, designing, budgeting, and implementing research studies internally and through external vendors
• Highly-developed problem solving and risk management skills, and attention to detail.
• Collaborative working skills with proven ability to motivate and develop others

• Ability to act as an external ambassador and to influence external organizations to enhance Corbus Pharmaceuticals’ reputation for scientific excellence.

All your information will be kept confidential according to EEO guidelines.