About This Role

This position is part of the analytical development function within the Pharma & CMC department.  

Successful candidate will be responsible for conducting comprehensive characterization of Pharma products (oligonucleotides and small molecules), including product impurities and degradants, using state-of-the-art technologies (LC-MS, GC-MS, HRMS, NMR, FTIR, etc.) to establish process and product knowledge. Furthermore, selected candidate will actively contribute to the advancement of innovative chemistries within the oligonucleotide programs by developing new analytical methods and product characterizations.

Collaboration across various functions, including AD, process development (PD), manufacturing, quality, and regulatory CMC teams, will be an essential aspect of this role. The individual may assume analytical development program representative (ADPR) responsibilities, supporting the development of oligonucleotide and small molecule products.

What You’ll Do

• Performs structural elucidation to support PD.
• Develops analytical methods for the comprehensive characterization of complex oligonucleotide and small molecule products, impurities, and degradants.
• Diagnoses challenges in PD, manufacturing, and life cycle management of commercial products through product characterization.
• Assesses novel analytical technologies and drive innovation in the realm of structure elucidation for oligonucleotide and small molecule products.
• Develops analytical control strategy for oligonucleotide and small molecule therapeutics, and authors regulatory sections as necessary as ADPR.
• Delivers concise written reports and engaging oral presentations that emphasize the scientific discoveries and their implications.
• Collaborates closely with scientists in other Pharma-AD teams and participates in the laboratory management and instrument maintenance.

Who You Are

• Enthusiastic for tackling complex analytical challenges to advance the development of oligonucleotide and small molecule therapeutics.
• Motivated to learn new techniques to become a subject matter expert.
• Able to work independently as well as collaboratively within a team setting.

Required Skills

• Ph. D. in chemistry, chemical engineering, pharmaceutical science, or related fields with 0-4 years of industrial experience related to drug development; or MS in related field with 4+ years of industrial experience.
• Experience in structural elucidation of unknown molecules through a variety of techniques, such as NMR, LC-MS, GC-MS, HRMS, MS/MS, etc.
• In-depth knowledge of NMR analysis of small molecules or oligonucleotide.

Preferred Skills

• Strong background in organic chemistry is a plus.

Why Biogen?

Our mission to find therapies for neurological and rare diseases is a unique focus within our industry and this shared purpose is what connects us as a team. We work together to overcome obstacles and to follow the science. We are resilient as we strive to make an impact on our patients’ lives and on changing the course of medicine. Together, we pioneer. Together, we thrive.

At Biogen, we are committed to building on our culture of inclusion and belonging that reflects the communities where we operate and the patients we serve. We know that diverse backgrounds, cultures, and perspectives make us a stronger and more innovative company, and we are focused on building teams where every employee feels empowered and inspired. Read on to learn more about our DE&I efforts.

All qualified applicants will receive consideration for employment without regard to sex, gender identity or expression, sexual orientation, marital status, race, color, national origin, ancestry, ethnicity, religion, age, veteran status, disability, genetic information or any other basis protected by federal, state or local law. Biogen is an E-Verify Employer in the United States.