Engineer III, Pilot Upstream, Gene Therapy
- Cambridge, MA
- Department: Technical Development
- Region: US
About This Role
The successful candidate will join a team of scientists responsible for the development of scalable cell culture and purification processes used for the clinical and commercial manufacturing of adeno-associated virus (AAV) gene therapy vectors. In addition, this person will need to effectively collaborate with different groups within Gene Therapy, Process Development, Research, and external parties.
What You'll Do
- Independently scale up upstream processes and execute laboratory experiments with minimal guidance
- Perform independent data recording, analysis, and troubleshooting
- Establish manufacturable large-scale cell culture and fermentation operations
- Document development work in concise reports and provide project updates in written and oral presentations
- Support maintenance tasks for laboratory instrumentation and collaborate with outside vendors/suppliers for new technology evaluations.
- identify and drive systems improvements across operations and technologies
- Interact with contract manufacturing organizations through technology transfer activities and person-in-plant support
Who You Are
To attain success in this position you will require to have strong knowledge around large-scale upstream development operations and to independently plan and execute projects and experiments across multiple viral vector and precursor production platforms to support pilot-scale material generation runs.
- Bachelor's degree Bioengineering, Biochemical Engineering, Chemical Engineering, Biochemistry or related discipline with 6+ years’ experience in Biotech / Biopharma industries
- Masters degree in Bioengineering, Biochemical Engineering, Chemical Engineering, Biochemistry or related discipline with 4+ years’ experience in Biotech / Biopharma industries
- Strong knowledge and experience in large-scale bioreactor or fermenter operations
- Knowledge and experience with viral vector related biology and/or manufacturing
- Proven record of successfully planning and executing projects and experiments
- Strong knowledge and experience in mammalian cell culture / bacterial fermentation / viral vector production operations (aseptic operations, cell biology, biochemistry, analytical techniques, bioreactor operations)
- Skilled in Word, Excel, Powerpoint, and other tools.
- Knowledge of statistical software applications, including DoE
- Strong analytical skills
Our mission to find therapies for neurological and rare diseases is a unique focus within our industry and this shared purpose is what connects us as a team. We work together to overcome obstacles and to follow the science. We are resilient as we strive to make an impact on our patients’ lives and on changing the course of medicine. Together, we pioneer. Together, we thrive.