Engineer I, Purification Process Development, Gene Therapy

  • Cambridge, MA
  • Full-time
  • Department: Technical Development
  • Region: US

Job Description

The Engineer I role may participate in project teams and in the scale-up and technology transfer of purification processes to the manufacturing organizations.  The candidate will be able to independently execute experiments, record and analyzes experimental data, propose conclusions, and recognize issues.  This individual will participate in investigating and evaluating novel technologies to improve current purification processes.  This individual will write and review technical development reports and will provide project updates in written and oral presentations.  In addition, this individual will interact with other departments such as cell culture development, analytical development, and manufacturing sciences and provide purification support to these groups.


The ideal candidate will hold a B.S. or M.S. (0-2 years of experience) in chemical or biochemical engineering, biochemistry, or a related field.  

  • An understanding of the fundamentals of protein chromatography and/or membrane separations is required.  
  • Hands-on experience with AKTA (Explorer, Avant, Pure) chromatography and filtration (TFF, NFF) systems is a plus.  
  • An understanding of virus properties and experience with the development of purification processes for viruses and viral vectors is desirable.  
  • Strong computer skills and good verbal and written communication skills are required.

Additional Information

Biogen is recruiting for an Engineer I, Purification Process Development, Gene Therapy. The successful candidate will join a team of engineers/scientists responsible for the development of purification processes used for the clinical and commercial manufacture of adeno-associated viral (AAV) vectors.  This individual will be involved in execution of multiple aspects of viral vector purification, including chromatography, filtration and membrane separations (TFF, UFDF, microfiltration, viral filtration, and depth filtration), and validation of viral and contaminant clearance. 

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