This is for a 12-week internship position from June - August 2020.

This summer internship involves collaborating with biostatisticians at Biogen to design and execute simulation studies to inform crucial decisions in both clinical trials and pre-clinical studies

In studies with two correlated outcomes, decisions to move the candidate drug to the next phase of development can be formalized under a Bayesian framework in which the outcomes are modeled jointly and a decision rule is pre-specified based on the posterior probabilities of a minimally meaningful treatment effect of each outcome. The goal of this summer internship is to develop a framework in R and Stan for performing simulations to support both pre-clinical and clinical studies using a Bayesian go/no-go decision rule for co-primary endpoints based on longitudinal data. The intern will design and execute a simulation study for a Phase II clinical trial and then develop a generalized simulation framework that can easily be applied to other clinical and pre-clinical studies. Being able to simulate different go/no-go study outcomes will help inform operating characteristics of the study and model and will help the statistician to introduce the concept of a Bayesian analysis and Bayesian decision rule to the study team.

To participate in the Biogen Co-op Program, students must meet the following eligibility criteria: 

• Legal authorization to work in the U.S. 
• Grade point average of 3.2 or higher preferred 
• At least 18 years of age prior to the scheduled start date 
• Be currently enrolled in an accredited college or university 

This summer internship involves collaborating with biostatisticians at Biogen to design and execute simulation studies to inform crucial decisions in both clinical trials and pre-clinical studies.