Bicycle Therapeutics is a clinical-stage pharmaceutical company developing a novel class of medicines, referred to as Bicycle® molecules, for diseases that are underserved by existing therapeutics. Bicycle molecules are fully synthetic short peptides constrained with small molecule scaffolds to form two loops that stabilize their structural geometry. This constraint facilitates target binding with high affinity and selectivity, making Bicycle molecules attractive candidates for drug development. The company is evaluating nuzafatide pevedotin (formerly 5528), a Bicycle® Drug Conjugate (BDC®) targeting EphA2, a historically undruggable target; zelenectide pevedotin (formerly BT8009), a BDC targeting Nectin-4, a well-validated tumor antigen; and BT7480, a Bicycle Tumor-Targeted Immune Cell Agonist® (Bicycle TICA®) targeting Nectin-4 and agonizing CD137, in company-sponsored clinical trials. Additionally, the company is developing Bicycle® Radioconjugates (BRC®) for radiopharmaceutical use and, through various partnerships, is exploring the use of Bicycle® technology to develop therapies for diseases beyond oncology.

Bicycle Therapeutics is headquartered in Cambridge, UK, with many key functions and members of its leadership team located in Lexington, Massachusetts, USA. For more information, visit bicycletherapeutics.com

Culture is key and all Bicycle employees actively embrace and role model our company values: 

• We are Adventurous. We believe it’s the way to deliver extraordinary results for our patients.   
• We are Dedicated to our Mission. You can’t change the world if you don’t have determination. 
• We are One Team. We only succeed when we work together.  

Your mission is to apply your scientific expertise to the design, execution and analyses of translational data packages derived for assets in our clinical oncology portfolio. Working as a key member of cross-functional teams, you will be responsible for developing and analyzing biomarker assay data from multiple modalities (IHC, NGS, FISH, imaging etc.) and contributing directly to the advancement of our novel Bicycle Drug Conjugates (BDCs) and Bicycle Radio Conjugates (BRCs) from discovery into the clinic, including companion diagnostics development.

Scientific Strategy & Innovation

• Contribute to the design and execution of translational strategies that align with project goals, focusing on the development of robust biomarker packages for patient selection, proof-of-mechanism, and pharmacodynamic assessment.
• Represent TSDx department on global project teams for nuzefatide pevedotin (BT5528) and zelenectide pevedotin (BT8009) to execute prioritized team biomarker strategy.
• Identify and champion opportunities for innovation across biomarker analytical methodologies proposing creative solutions and new approaches to solve scientific challenges.

Project Delivery & Execution

• Independently perform and oversee quantitative analysis of biomarker data sets from clinical studies, through management of activities at third party laboratories (e.g. CROs and/or academic collaborators), to ensure delivery of high-quality, timely, interpretable results.
• Lead authorship of biomarker sections of team technical documents, such as clinical protocols, investigator brochure, lab manual, and regulatory briefing books as required. Seek opportunities to contribute to present clinical biomarker data packages via external scientific publications.
• Present scientific findings and their interpretation clearly and effectively at project team meetings and to cross-functional stakeholders.

• Demonstrated expertise in a biopharmaceutical setting of design, delivery, analysis and interpretation of clinical biomarker data (e.g. IHC, NGS, FISH, imaging etc.), in oncology clinical trials (solid or liquid tumors).
• Demonstrated capability of delivering clinical biomarker assay development at third party laboratories within the context of a clinical trial. Experience working as biomarker lead within global oncology project teams is highly desirable.
• Familiarity with and experience of the regulatory requirements of conducting clinical biomarker studies, up to and including companion diagnostics would be an advantage.
• Advanced degree (MS, PhD, or equivalent) in a relevant scientific discipline is preferred

Values & Behaviours: 
Knowledge & Expertise

• Core Expertise: You apply strong scientific expertise to confidently design and execute clinical biomarker studies.
• Data / Insight: You independently interpret complex clinical biomarker data, identifying patterns, drawing conclusions, and understanding the implications for the project.
• Knowledge Sharing: You actively build collective expertise by sharing learnings and mentoring more junior colleagues.

Job Complexity

• Task / Project Delivery: You independently deliver work of moderate to high complexity, managing multiple responsibilities and contributing to significant project milestones.
• Problem-Solving: You anticipate scientific challenges and develop practical, creative solutions when they arise.
• Strategic Impact: You provide key data and scientific insights that directly inform project decisions and shape team priorities.

Independence

• Autonomy: You operate independently in your daily research activities, requiring minimal supervision on routine work.
• Decision-Making: You select suitable methods and approaches with sound scientific judgment, making informed decisions that influence team success.
• Leadership / Mentorship: You mentor junior colleagues and act as a source of technical expertise, sharing best practices and supporting their development.

• State-of-the-art campus environment with on campus restaurant and Montessori nursery
• Flexible working environment
• Competitive reward including annual company bonus 
• Employee recognition schemes
• 28 days annual leave in addition to bank holidays + option to buy up to 5 additional days annually
• Employer contribution to pension (employee does not have to contribute) 
• Life assurance cover 4x basic salary 
• Private Medical Insurance, including optical and dental cover 
• Enhanced parental leave policies
• Group income protection
• Employee assistance program
• Health Cash Plan
• Access to company subsidized gym membership
• Eligibility for an option grant to subscribe to shares in Bicycle Therapeutics plc. 
• Cycle to work scheme 

Bicycle Therapeutics is committed to building a diverse workforce that is representative of the communities we serve. We recognize that diverse and inclusive teams build a stronger and more innovative company. Therefore, all qualified applicants will be considered for employment, and we do not discriminate on the basis of race, religion, colour, gender, sexual orientation, age, disability status, marital status, or veteran status.

Bicycle Therapeutics is committed to building a diverse workforce that is representative of the communities we serve. We recognize that diverse and inclusive teams build a stronger and more innovative company. Therefore, all qualified applicants will be considered for employment, and we do not discriminate on the basis of race, religion, colour, gender, sexual orientation, age, disability status, marital status, or veteran status.