Bicycle Therapeutics is a clinical-stage biopharmaceutical company developing a novel class of medicines, referred to as Bicycle® molecules, for diseases that are underserved by existing therapeutics. Bicycle molecules are fully synthetic short peptides constrained with small molecule scaffolds to form two loops that stabilize their structural geometry. This constraint facilitates target binding with high affinity and selectivity, making Bicycle molecules attractive candidates for drug development. The company is evaluating zelenectide pevedotin (previously BT8009), a Bicycle® Toxin Conjugate (BTC®) targeting Nectin-4, a well-validated tumor antigen; BT5528, a BTC targeting EphA2, a historically undruggable target; and BT7480, a Bicycle Tumor-Targeted Immune Cell Agonist® (Bicycle TICA®) targeting Nectin-4 and agonizing CD137, in company-sponsored clinical trials. Additionally, the company is developing Bicycle® Radio Conjugates (BRC™) for radiopharmaceutical use and, through various partnerships, is exploring the use of Bicycle® technology to develop therapies for diseases beyond oncology. 

Bicycle Therapeutics is headquartered in Cambridge, UK, with many key functions and members of its leadership team located in Cambridge, Massachusetts.  

Culture is key and all Bicycle employees actively embrace and role model our company values:

• We are Adventurous. We believe it’s the way to deliver extraordinary results for our patients.  
• We are Dedicated to our Mission. You can’t change the world if you don’t have determination. 
• We are One Team. We only succeed when we work together.

The Senior Director/Director of New Product Strategy and Commercialization (NPSC) is responsible for shaping the Bicycle Therapeutics strategy and pipeline, as part of the New Product Strategy and Commercialization Team. You will play a key role in four critical areas: development of the early portfolio strategy and landscape assessment, commercial input on impact and life cycle potential of new products, commercial leadership across multiple cross-functional teams for products moving from pre-clinical stages through early clinical development, and oversight of corporate competitive intelligence efforts across the portfolio.

The NPSC leader will be expected to partner with all core functions (Research & Innovation, Investor Relations, Business Development, late-stage Commercial, Clinical Development, etc.) on the four critical areas. On an ongoing basis, you will represent their projects within internal governance meetings, planning and budget cycles. This role follows a hybrid work structure where employees can work remotely or from the office, as needed.

Key responsibilities:

• Actively partner with cross-functional teams to provide strategic and commercial direction on pipeline planning and product development and ensure appropriate early commercial planning and execution
• Develop the early commercial strategy for key assets, ensuring alignment corporate goals and strategy
• Support development and execution of disease-area-strategy and ensure prioritization of internal and external growth opportunities in line with each disease-area-strategy
• Direct integrated market analysis and competitive intelligence investigations to identify current and future trends within key targets and disease settings, various patient segments in multiple tumor types, and multiple modalities (immunotherapy, cytotoxic drug conjugates, and radioligand based therapies, etc.)
• Understand and communicate requirements for regulatory approval (registration), access to market (pricing and reimbursement), and market differentiation required for the successful commercialization of new oncology products
• Lead the identification of key value drivers and translate these into tangible value proposition elements and key decision criteria for commercial success
• Translate key Insights from scientific experts (internal R&D colleagues + external opinion leaders) into clear, actionable strategies for the portfolio
• Ensure early development strategy and activities in scope with NPP function are well coordinated
• Support the team by providing commercial leadership within various internal governance forums
• Work with R&I, Clinical Development, Portfolio Strategy, and later-stage Commercial colleagues to define and evolve disease areas/commercial areas of interest
• Lead or provide input into revenue forecast development for new product assessments and early-stage assets
• Anticipate and ensure smooth transition of all commercial deliverables and insights to the later-stage Commercial and Marketing team

• Undergraduate degree in business or science or related discipline required, advanced terminal degree preferred (MBA, PhD, PharmD etc.)
• At least 5 years of related experience in some combination of pharmaceutical marketing, new product planning, market access and/or strategy consulting
• Significant experience in oncology is preferred, especially with solid tumours, and experience across a range of therapeutic modalities is a plus
• Ability to develop and implement strategies based on trends and opportunities in the pharmaceutical industry and the overall health care environment
• A strong business orientation and the ability to view issues from multiple functional perspectives
• Strategic thinking and ability to effectively communicate the asset strategy to stakeholders of varied backgrounds and within deliverables for internal and external audiences
• Strong analytical and organizational skills
• Ability to engage credibly with internal and external stakeholders of varied levels of expertise around scientific topics
• Experience working collaboratively and cross-functionally with brand marketing teams, market research, sales, market access, medical affairs, business development, regulatory, research & development, clinical, manufacturing, finance and legal
• Excellent interpersonal, communication, and presentation skills with the ability to interface seamlessly with other parts of the organization

• State-of-the-art campus environment with on campus restaurant and Montessori nursery
• Flexible working environment
• Competitive reward including annual company bonus 
• Employee recognition schemes
• 28 days annual leave in addition to bank holidays + option to buy up to 5 additional days annually
• Employer contribution to pension (employee does not have to contribute) 
• Life assurance cover 4x basic salary 
• Private Medical Insurance, including optical and dental cover. 
• Group income protection
• Employee assistance program
• Health Cash Plan
• Access to company subsidized gym membership.
• Eligibility for an option grant to subscribe to shares in Bicycle Therapeutics plc. 
• Cycle to work scheme 

Bicycle Therapeutics is committed to building a diverse workforce that is representative of the communities we serve. We recognize that diverse and inclusive teams build a stronger and more innovative company. Therefore, all qualified applicants will be considered for employment, and we do not discriminate on the basis of race, religion, colour, gender, sexual orientation, age, disability status, marital status, or veteran status.