Bicycle Therapeutics is a clinical-stage pharmaceutical company developing a novel class of medicines, referred to as Bicycle® molecules, for diseases that are underserved by existing therapeutics. Bicycle molecules are fully synthetic short peptides constrained with small molecule scaffolds to form two loops that stabilize their structural geometry. This constraint facilitates target binding with high affinity and selectivity, making Bicycle molecules attractive candidates for drug development. The company is evaluating zelenectide pevedotin (formerly BT8009), a Bicycle® Toxin Conjugate (BTC®) targeting Nectin-4, a well-validated tumor antigen; BT5528, a BTC molecule targeting EphA2, a historically undruggable target; and BT7480, a Bicycle Tumor-Targeted Immune Cell Agonist® (Bicycle TICA®) targeting Nectin-4 and agonizing CD137, in company-sponsored clinical trials. Additionally, the company is developing Bicycle® Radio Conjugates (BRC™) for radiopharmaceutical use and, through various partnerships, is exploring the use of Bicycle® technology to develop therapies for diseases beyond oncology.

Bicycle Therapeutics is headquartered in Cambridge, UK, with many key functions and members of its leadership team located in Cambridge, MA USA

Culture is key and all Bicycle employees actively embrace and role model our company values: 

• We are Adventurous. We believe it’s the way to deliver extraordinary results for our patients.   
• We are Dedicated to our Mission. You can’t change the world if you don’t have determination. 
• We are One Team. We only succeed when we work together.  

We are seeking a Biomarker Operations Senior Associate to join the Translational Sciences team. This position is highly cross-collaborative, working at the interface of Translational Sciences, Clinical Operations, Data Management and partner CROs. As a key member of a multi-faceted team, you will seamlessly bridge science and operations to support study-specific clinical biomarker strategies. You will be responsible for coordinating all aspects of biomarker operations activities from guiding central laboratory set-up, to overseeing sample management lifecycle, data reporting and reconciliation.

• Work collaboratively with the Translational Science and Clinical Operations teams to:
  • Support review of biomarker sections in protocols, central laboratory specifications and lab manuals, consent forms, sample analysis plans
  • Manage the implementation of biomarker logistics with the central laboratory throughout the life of the trial
  • Proactively follow-up on biomarker sample and data related queries
• Become the subject matter expert for study-specific biomarker sample lifecycle, from sample collection, shipment, testing, data transfer, and final disposition
• With Data Management, support the review of data transfer agreements and the reconciliation of biomarker data and samples
• Establish biomarker related processes to ensure consistency across clinical trials
• Develop and maintain long-term storage framework for clinical and pre-clinical samples

Essential:  

• Clinical trial experience
• Strong organizational and time management skills
• Attention to detail and accuracy
• Ability to collaborate, communicate,
• Proficiency in Microsoft Office Suite
• Scientific background and basic understanding of data analysis
• Flexible, organized and motivated individual who enjoys working in a fast-paced, small company environment

Desirable:  

• Proficiency in Smartsheets

• Flexible working environment
• Competitive reward including annual company bonus
• Medical, dental, and vision insurance for eligible employees and their families with 100% of the premiums covered by the Company
• Health and Dependent Care Flexible Spending Accounts
• 401(k) plan with a 4% Company match and immediate vesting
• Eligibility to accrue up to 23 paid time off days per full year worked, plus the option to buy up to 5 additional days
• Employee assistance program
• Employee recognition schemes
• 10 Company holidays
• Competitive Family Leave Policy
• Eligibility for an option grant to subscribe to shares in Bicycle Therapeutics plc.

Bicycle Therapeutics is committed to building a diverse workforce that is representative of the communities we serve. We recognize that diverse and inclusive teams build a stronger and more innovative company. Therefore, all qualified applicants will be considered for employment, and we do not discriminate on the basis of race, religion, colour, gender, sexual orientation, age, disability status, marital status, or veteran status.