Bicycle Therapeutics is a clinical-stage pharmaceutical company developing a novel class of medicines, referred to as Bicycle® molecules, for diseases that are underserved by existing therapeutics. Bicycle molecules are fully synthetic short peptides constrained with small molecule scaffolds to form two loops that stabilize their structural geometry. This constraint facilitates target binding with high affinity and selectivity, making Bicycle molecules attractive candidates for drug development. The company is evaluating zelenectide pevedotin (formerly BT8009), a Bicycle® Toxin Conjugate (BTC®) targeting Nectin-4, a well-validated tumor antigen; BT5528, a BTC molecule targeting EphA2, a historically undruggable target; and BT7480, a Bicycle Tumor-Targeted Immune Cell Agonist® (Bicycle TICA®) targeting Nectin-4 and agonizing CD137, in company-sponsored clinical trials. Additionally, the company is developing Bicycle® Radio Conjugates (BRC™) for radiopharmaceutical use and, through various partnerships, is exploring the use of Bicycle® technology to develop therapies for diseases beyond oncology.

Bicycle Therapeutics is headquartered in Cambridge, UK, with many key functions and members of its leadership team located in Cambridge, Mass.

Culture is key and all Bicycle employees actively embrace and role model our company values:  

• We are Adventurous. We believe it's the way to deliver extraordinary results for our patients.
• We are Dedicated to our Mission. You can't change the world if you don't have determination
• We are One Team. We only succeed when we work together. 

We are looking for a highly motivated and experienced Project Manager with a proven track record of successful pipeline project delivery to provide project management across the Research organisation.

In this role, you will be responsible for driving the planning and activities required for successful delivery of our portfolio of projects in close partnership with Research Project Leaders (PLs). 

Key Responsibilities:

Technical:

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• Management of complex projects, including planning, timelines, budget oversight, proactive identification and assessment of challenges and risks, management of inefficiencies and potential resource bottlenecks and leading “lessons learned” within the program to ensure continuous improvement.
• With the Project Leader's, develop and prioritize key program objectives, go/no-go decisions and data review based on key milestones.
• Provide support where needed to Project Leader's on the management and delivery of projects and the use of project management tools.
• As part of the broader company Program Management organization, share and contribute to project management best practices.

Leadership:

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• Serve as the Lead Project Manager for Research, fostering collaboration, high performance, and a results-orientated mindset.
• Drive the planning and execution of the integrated project plan (to IND filing) to:
  • Set realistic yet ambitious timelines for achieving objectives.
  • Ensure project objectives and critical milestones are met to high quality, on time and within scope and budget.
  • Align project plans and interdependencies with key stakeholders across nonclinical, translational, clinical, regulatory, CMC, medical affairs, and commercial.
• Closely monitor plan execution and proactively collaborate with team members to drive completion of deliverables, manage issues and correct deficiencies
• Chair project team (PT) meetings, and in partnership with the Project Leader, present project plans, progress, risks and issues to functional and senior management and governance boards.

Cultural Fit:

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• Promote innovative approaches to problem solving, communicate ideas persuasively, decisively confront and resolve issues and work constructively under pressure.
• Excellent communication and interpersonal skills; collaborate sensitively and effectively with stakeholders across functions to align on priorities and make sure that interdependencies are clear.
• Embrace rapid change and ambiguity, proactively identifying opportunities for improving ways of working within the program.
• Build strong relationships with internal and external stakeholders, fostering a collaborative and inclusive work environment.
• Communicate effectively with senior leadership in a clear, concise, and confident matter.

• Educated in life sciences, engineering, or related field
• Extensive experience in project management within the biopharmaceutical industry
• Knowledge of the drug discovery and development process (preferably oncology) from early discovery phase to IND filing
• Proven track record of successfully driving the execution of complex projects.
• Strong project management skills, with experience implementing tools and processes to streamline operations and improve efficiency. Project management certification (e.g., PMP or PRINCE2) ideal but not essential
• Demonstrated ability to thrive in a fast-paced, dynamic environment and adapt to evolving business needs.

• State-of-the-art campus environment with on campus restaurant and Montessori nursery
• Flexible working environment
• Competitive reward including annual company bonus 
• Employee recognition schemes
• 28 days annual leave in addition to bank holidays + option to buy up to 5 additional days annually
• Employer contribution to pension (employee does not have to contribute) 
• Life assurance cover 4x basic salary 
• Private Medical Insurance, including optical and dental cover. 
• Group income protection
• Employee assistance program
• Health Cash Plan
• Access to company subsidized gym membership.
• Eligibility for an option grant to subscribe to shares in Bicycle Therapeutics plc. 
• Cycle to work scheme 

Bicycle Therapeutics is committed to building a diverse workforce that is representative of the communities we serve. We recognize that diverse and inclusive teams build a stronger and more innovative company. Therefore, all qualified applicants will be considered for employment, and we do not discriminate on the basis of race, religion, colour, gender, sexual orientation, age, disability status, marital status, or veteran status.